Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:Muhammad Iqbal emerged during a period of intellectual stagnation in the Muslim world in the early 20th century, introducing a fresh and visionary idea: the reconstruction of religious thought. In his seminal work, The Reconstruction…
Reconstruction of Religious Thought in Islam, Iqbal proposed a way out of this stagnation by revitalizing the Islamic intellectual heritage while engaging in a critical dialogue with modernity. This study aims to examine the key concepts of Iqbal's project, including his critique of Greek philosophy, his dynamic view of ijtihad (legal reasoning), his theory of the "Khudi" (Self), his dynamic concept of God and the universe, and his vision of spiritual democracy. Using a qualitative approach with philosophical-hermeneutic analysis, this research concludes that while Iqbal's thought has been widely appreciated as a revitalizing force for Islamic intellectualism, it has also faced criticism concerning its practical implementation and philosophical consistency. The study finds that Iqbal's ideas remain profoundly relevant today, particularly in navigating the challenges of modernity without sacrificing Islamic identity.
Abstract:This study aims to analyze the influence of leadership style, organizational culture, and work motivation on organizational commitment among library staff of public senior high schools (SMA Negeri) in Jambi Province, both…
h directly and indirectly. The research employed a quantitative approach with a cluster sampling technique across three regions Jambi City, Tanjung Jabung Timur Regency, and Merangin Regencywith a total of 132 respondents, 97 of whom were included in the analytical sample. Data were processed using SmartPLS 3.0 through structural model testing (inner model) to examine causal relationships among variables.The results indicate that leadership style does not have a significant direct effect on work motivation, whereas organizational culture shows a strong and significant direct effect on the work motivation of library staff. Additionally, leadership style and organizational culture jointly have a significant impact on work motivation. Regarding organizational commitment, the findings reveal that leadership style, organizational culture, and work motivation each have a positive and significant direct effect. Further results show that both leadership style and organizational culture exert significant indirect effects on organizational commitment through work motivation, suggesting that work motivation functions as a mediating variable in these relationships.
Overall, this study concludes that organizational culture is the most dominant factor influencing both work motivation and organizational commitment, while work motivation strengthens the relationship between leadership and cultural factors and the commitment of library staff. Therefore, efforts to enhance organizational commitment among library personnel in public senior high schools in Jambi Province should focus on cultivating a positive organizational culture, improving effective leadership practices, and providing continuous motivational support.
Abstract:The development of a green economy is a strategic issue in realizing sustainable development, especially in potential areas such as Lake Toba. However, the role of socio-cultural factors in supporting the green economy has…
as not been extensively researched empirically. This study aims to analyze the influence of Community Awareness, Environmental Knowledge, and Local Cultural Beauty on Green Economic Development in the Lake Toba area. The method used is a quantitative approach with multiple linear regression analysis techniques with the help of SPSS software version 25. Data were obtained from questionnaires distributed to local respondents The results of the study showed that Community Awareness and Environmental Knowledge did not have a significant effect on the green economy, while the Beauty of Local Culture had a significant effect. The value of the determination coefficient (R²) of 0.4053 indicates that the three variables explain the 40.5% variation in the development of the green economy. These findings confirm the importance of a cultural approach in supporting the sustainability of the Lake Toba region.
Abstract:This study aims to analyze the factors influencing the attitudes and decisions of lower-class communities in adopting Islamic bank mobile banking services, with a specific focus on the BSI Mobile application. The research…
h applies the Technology Acceptance Model (TAM) developed by Davis (1989), emphasizing two key constructs—perceived ease of use and perceived usefulness—as determinants of users’ attitudes and decisions. The study employs a quantitative approach using a survey method involving 100 lower-class customers of Bank Syariah Indonesia (BSI) Sibuhuan. Data were analyzed using Structural Equation Modeling (SEM) with the Partial Least Squares (PLS) technique through SmartPLS 4.0 software. The results indicate that perceived usefulness significantly affects both attitude and decision to use, while perceived ease of use influences attitude indirectly. The R² value for attitude (0.743) and decision (0.654) shows that the model has strong explanatory power. These findings reveal that lower-income customers are more motivated by perceived benefits, such as convenience, time efficiency, and transaction security, rather than interface simplicity. From a practical perspective, the study suggests that Islamic banks should strengthen digital literacy, user assistance, and customer trust to enhance mobile banking adoption among lower-class communities.
Abstract:Gender issues in public spaces and Muslim communities have increasingly gained attention in academic discourse due to their strong connection with social norms, cultural values, and religious interpretations that shape women's…
omen's patterns of participation. This study aims to examine the influence of gender norms and values within Muslim communities on women’s engagement in public spaces, uncover the challenges they face, and formulate recommendations based on feminist and social constructionist perspectives to promote gender equality. The research employs a Systematic Literature Review (SLR) method by tracing reputable academic databases through rigorous selection and thematic analysis. The findings reveal that Muslim women’s participation in public spaces is often hindered by patriarchal constructions, discrimination, and limited access. Nevertheless, women have developed strategies of resistance and negotiation that expand their roles. Thematic analysis identifies three main patterns: women’s representation in public spaces, gender-based social practices that impose limitations, and resistance strategies through religious reinterpretation and community activism. This article contributes to theoretical development by enriching global feminist perspectives through the lived experiences of Muslim women while also offering practical contributions in the form of inclusive and socially–religiously sensitive public policy recommendations. The implications highlight the importance of cross-cultural studies and the exploration of women’s experiences at the local community level to broaden understanding of gender equality in contemporary Muslim societies.
Abstract:This research aims to develop a mathematics learning device oriented toward the Realistic Mathematics Education (RME) approach based on Ethnomathematics to improve students’ mathematical problem-solving skills at MTs Negeri…
egeri 3 Tapanuli Selatan. The study employed a Research and Development (R&D) design using the 4-D model, which consists of four stages: defining, designing, developing, and disseminating. The research subjects were 36 seventh-grade students in the second semester of the 2022/2023 academic year. The instruments used included expert validation sheets, teacher and student practicality questionnaires, classroom observation sheets, and mathematical problem-solving tests. The results revealed that the developed learning device achieved an average expert validation score of 4.25 in the very valid category in terms of content, language, and presentation. The practicality test showed that the teacher’s response reached 89% and the students’ response reached 91%, categorized as very practical, indicating that the device was easy to use and engaging for students. The effectiveness test showed an average N-Gain score of 0.52 (moderate category) with 86.11% of students achieving mastery learning, signifying that the learning device was effective in enhancing students’ mathematical problem-solving abilities.
The integration of the realistic mathematics approach with local cultural elements (ethnomathematics) successfully created meaningful and contextual learning experiences while fostering students’ appreciation for their cultural heritage. Therefore, the developed learning device is feasible to be implemented as an innovative mathematics learning medium based on cultural contexts in junior high schools and madrasah.
Abstract:This study aims to identify the petrological and petrographical characteristics of carbonate rocks that act as natural asphalt (Asbuton) reservoir rocks in the Winning area, Buton Regency. The analysis was conducted through…
ugh megascopic observation of rock outcrops and microscopic observation of thin sections using a polarizing microscope. The results show that the carbonate rock units in the study area are dominated by bioclastic limestone (biomicrite) and dolomitic limestone (biogenic dolomite). The bioclastic limestone consists of foraminiferal and shell fragments bound by micrite and sparry calcite cement, whereas the dolomitic limestone displays fine- to medium-crystalline textures with well-developed intercrystalline porosity formed through dolomitization. Partial to advanced dolomitization occurred due to the circulation of magnesium-rich fluids in a restricted marine environment during the post-depositional stage. The mineralogical transformation from calcite to dolomite enhanced both porosity and compactness, making these rocks potential reservoir rocks for natural asphalt accumulation. Overall, the petrological and petrographical characteristics indicate that the carbonate rocks in the Winning area underwent a complex diagenetic evolution and play a significant role in the formation and entrapment system of Buton Rock Asphalt (Asbuton).
Abstract:This study aims to identify the local government’s policy strategy in developing tourism in North Galesong, Takalar Regency. The research uses a qualitative method, with data collected through observation, interviews, and…
and documentation. The informants in this study consist of five individuals with different occupational backgrounds. The findings show that: (1) The local government’s strategy for developing tourism in North Galesong focuses on infrastructure development, digital promotion, and community empowerment through Pokdarwis (Tourism Awareness Group) training. Although there are still challenges such as limited facilities, insufficient promotion, and uneven mentoring, this strategy demonstrates the government’s commitment to achieving sustainable tourism. However, more systematic planning, technological support, and active community participation are needed to enhance tourism attractiveness. (2) The process of formulating the tourism development strategy begins with identifying obstacles such as limited funding and human resources, which are addressed through collaboration among the government, community, academics, and private sector. Strategic priorities are determined by considering economic factors, local culture, and environmental sustainability. Furthermore, the community is empowered through Pokdarwis and supported by village funds, culminating in the implementation of a pentahelix collaboration model to ensure that the strategy is well-directed, participatory, and sustainable.
Abstract:The mass media, as a means of providing information, plays an important role in disseminating issues that arise in society. More specifically, the mass media has the power to spread public opinion. This study aims to analyze…
lyze the extent to which mass media exposure can influence the formation of public opinion regarding government policies in the Social Services Agency of Gowa Regency and to determine the extent to which public opinion influences the implementation of government policies in the Social Services Agency of Gowa Regency. This study uses a quantitative approach with a data collection technique, namely a questionnaire, administered to 100 respondents. The focus of this study is the extent to which mass media exposure can influence the formation of public opinion regarding government policies at the Social Services Agency. The data analysis techniques used in this study were simple linear regression, T-test (partial), F-test (simultaneous), and coefficient of determination. The results of the study show that, partially, the mass media has a positive and significant effect on public opinion, while public opinion has a negative effect on the implementation of government policies.