Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:This study aims to identify the petrological and petrographical characteristics of carbonate rocks that act as natural asphalt (Asbuton) reservoir rocks in the Winning area, Buton Regency. The analysis was conducted through…
ugh megascopic observation of rock outcrops and microscopic observation of thin sections using a polarizing microscope. The results show that the carbonate rock units in the study area are dominated by bioclastic limestone (biomicrite) and dolomitic limestone (biogenic dolomite). The bioclastic limestone consists of foraminiferal and shell fragments bound by micrite and sparry calcite cement, whereas the dolomitic limestone displays fine- to medium-crystalline textures with well-developed intercrystalline porosity formed through dolomitization. Partial to advanced dolomitization occurred due to the circulation of magnesium-rich fluids in a restricted marine environment during the post-depositional stage. The mineralogical transformation from calcite to dolomite enhanced both porosity and compactness, making these rocks potential reservoir rocks for natural asphalt accumulation. Overall, the petrological and petrographical characteristics indicate that the carbonate rocks in the Winning area underwent a complex diagenetic evolution and play a significant role in the formation and entrapment system of Buton Rock Asphalt (Asbuton).
Abstract:This study aims to analyze and identify how the news of "Former Chicken Cage Becomes School" represents the inequality of access to education with the framework of Norman Fairclough's critical discourse analysis. This study…
udy adopts a descriptive qualitative method using Norman Fairclough's critical discourse analysis (AWK) as the main framework. Data is collected through documentation and recording of news texts from relevant online media. Data analysis was carried out sequentially covering Fairclough's three dimensions: microstructural analysis (word choice, sentence structure, rhetorical strategy), mesostructural analysis (the practice of production and distribution of news texts), and macrostructural analysis (social and ideological relationships that underlie discourse). The results of this study reveal the complex representation of inequality in access to education through critical discourse analysis (AWK) on the news "Former Chicken Cage Becomes School" with the Norman Fairclough approach. Microstructurally, word choice and sentence structure build a narrative of struggle and implicit criticism of the system. At the mesostructural level, local MATAMAROS.COM strategic media frame this issue as an urgent social issue, including publication during National Education Day 2025 to maximize impact. Macrostructurally, the news reflects structural inequality due to geographical/economic marginalization, reinforces the ideology of "unsung heroes," and highlights the power imbalance. This descriptive qualitative research concludes that the news is a strong linguistic construct, aiming to mobilize public opinion on inequality in access to education, while reflecting the issue of unequal development and the role of actors in social justice
Abstract:This study aims to analyze the patterns, characteristics, and effectiveness of educational supervision in inclusive school settings through a systematic literature review approach. The methodology used PRISMA 2020 with a…
literature search in five international databases for the period 2021-2025, resulting in 20 high-quality articles for analysis. The findings show the evolution of supervision models from a traditional hierarchical approach to a collaborative-transformational paradigm. Four effective supervision models were identified: transformational supervision, instructional leadership supervision, collaborative supervision, and distributed leadership model. The transformational supervision model showed significant changes in teachers' attitudes toward inclusive education, while instructional leadership had a 63.7% correlation with student academic achievement. Components of effective supervision include academic aspects through curriculum and IEP adaptation, professional aspects through teacher self-efficacy development, and organizational aspects through systematic management. Internal factors such as supervisor competence and an inclusive culture, as well as external factors such as policy support, determine successful implementation. Key challenges include issues of bullying, technological barriers, and the complexity of AI integration in supervision. The study recommends developing a contextual supervision model for Indonesia, taking into account local cultural characteristics and resource availability.
Abstract:Historical records show that in the early 19th century, Banten became a center for scholars in the archipelago and even in Southeast Asia, particularly in the field of Islamic studies. The Bantenese culture, which appears…
s simple on the surface, actually possesses a high level of complexity. This article presents a portrait of Bantenese culture by focusing on two main topics: the Debus tradition and the Panjang Mawlid tradition. The study finds that the diverse folk art performances in Banten, which have been passed down through generations, are inseparable from religious influences, especially Islam.
Abstract:Home birth selection is a complex decision influenced by various factors. This study aimed to determine the relationship between knowledge and antenatal care (ANC) visits with the decision-making of home birth in the working…
king area of Mapaddegat Public Health Center, Mentawai Islands Regency. This research was a descriptive analytic study with a case-control design, conducted from February to May 2025, involving mothers who gave birth and were recorded in the maternal cohort data from January 2023 to December 2024. A systematic random sampling technique was applied, consisting of 21 respondents in the case group and 42 respondents in the control group. Data were analyzed using univariate and bivariate analysis with the chi-square statistical test. The univariate results showed that 74.6% had high knowledge, and 57.2% had more than four ANC visits. The bivariate analysis revealed a significant relationship between knowledge (p = 0.011; OR = 5.455) and the number of ANC visits (p = 0.015; OR = 4.462) with the decision to give birth at home. It can be concluded that there is a relationship between knowledge and the number of ANC visits with home birth decision-making. It is recommended for the Mapaddegat Public Health Center staff to strengthen health promotion regarding delivery in health facilities and develop innovations to increase the coverage of facility-based deliveries.
Abstract:This study examines the concept of social solidarity and religious values, especially those contained in the Qur'an. Social solidarity has long been the focus of discussion in various disciplines, ranging from sociology,…
political science, to Islamic studies. In the midst of the increasingly complex dynamics of urbanization in Indonesia, the question of how religious values, especially those contained in the Qur'an, can encourage collective action based on social justice is very relevant. By examining in depth the relationship between the teachings of the Qur'an and social solidarity, this article contributes to the development of social theory and practice in urban Indonesian society. It is hoped that the findings and recommendations presented can be a reference for academics, researchers, and policymakers in formulating strategies for integrating Islamic values into contemporary social dynamics, so that in the end it can produce a more just, inclusive, and dignified society. The results of the study show that there is a strong integration between the theological message in the Qur'an and the dynamics of social interaction, as well as its implications in the formation of pro-people public policy. Thus, the conceptual framework proposed in this study not only makes a theoretical contribution to the development of Islamic studies and sociology, but also offers practical recommendations that are applicable to the strengthening of social solidarity in the modern era. This study suggests that further studies can explore more empirical aspects, involving field data and participatory analysis, to ensure that the values of the Qur'an are truly integrated into social life and public policy as a whole. This research invites further dialogue between stakeholders in an effort to realize solid social solidarity, as a tangible manifestation of the application of the principles of goodness and justice enshrined in the Qur'an.
Abstract:The integration of artificial intelligence (AI) in patent systems has emerged as a complex area in intellectual property law. This systematic literature review follows PRISMA 2020 guidelines to analyze AI implementation…
in patent systems, particularly within the Indonesian context. The study examines 11 key studies published between 2015-2025 through systematic searches across multiple academic databases. Results demonstrate that AI implementation has achieved significant improvements in operational efficiency, particularly in automated patent classification, prior art searching, and examination support systems. Approximately 190,000 AI patents were granted globally between 2000-2022, reflecting increasing technological importance. In Indonesia, AI implementation must align with Law No. 13 of 2016 on Patents as amended by Law No. 65 of 2024. The landmark Thaler v. Vidal case confirms AI cannot be an "inventor" but can serve as an assistive tool with significant human contribution. Key challenges include AI decision-making transparency and knowledge gaps among patent examiners.
Abstract:This This study aims to explore and analyze research trends related to competence in business, particularly within the context of small and medium-sized enterprises (SMEs), using a bibliometric approach. Data was extracted…
ed from the Scopus database and visualized using VOSViewer, facilitating the identification of key research clusters, influential authors, and the relationships between various keywords within the domain. The findings reveal significant clusters centered around "competence," "innovation," and "business performance," highlighting the integral role of innovation in enhancing business competencies. Additionally, the analysis emphasizes the interconnectedness of human resource development and strategic business planning with competency development. This research contributes to a comprehensive understanding of the complexities in business competence studies and underscores the importance of a multidisciplinary approach in fostering sustainable business success. The results provide valuable insights for both researchers and practitioners in the field of business competence.
Abstract:The use of social media in political campaigns significantly impacts the political awareness of first-time voters at SMAN 15 Garut. Validity and reliability tests of the research instrument indicate that the questionnaire…
e used is valid and reliable, allowing for accurate measurement of the desired concepts. Simple linear regression analysis reveals a positive relationship between the social media use variable (X) and the level of voter political awareness (Y), with social media explaining approximately 23.1% of the variation in voter awareness. Although significant, the influence of social media does not explain the entire variation in voter political awareness. Other factors outside the research variables also contribute, indicating the complexity in understanding the factors that influence the political awareness of first-time voters. Therefore, it is suggested to integrate social media use into better political campaign strategies, considering the characteristics of first-time voters. Increased digital access and knowledge also need to be strengthened so that first-time voters can participate more actively and effectively in the democratic process.