Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:The development of digital technology brings both challenges and opportunities for families in managing household finances. Low financial literacy and limited use of technology have caused some families to struggle in achieving…
hieving financial independence. This community service activity aims to enhance family financial independence through socialization, digital financial literacy training, and technology-based business mentoring. The implementation methods include problem identification, delivery of financial literacy materials, practical use of digital financial applications, and online entrepreneurship assistance. The results show an increase in families’ knowledge of budgeting, saving, and utilizing digital platforms to generate additional income. Thus, this program contributes to the creation of more financially independent families in the digital era.
Abstract:Arabic in the Generation Z era faces significant learning changes along with the development of digital technology and the unique characteristics of this generation known as digital natives . This study aims to identify…
challenges and opportunities in the Arabic language learning process among Gen Z using a literature review approach to various recent studies. The research method uses a literature review by reviewing 30 articles in several published national journals. The results of the study indicate that the main challenges include low digital literacy among educators, limited technological infrastructure, and the dominance of traditional learning methods that are less attractive to Gen Z. However, on the other hand, there are great opportunities through the use of technology such as social media, interactive learning applications, gamification, and blended learning approaches that can increase motivation and learning participation. This study recommends the need for curriculum development that is adaptive to the needs of Gen Z, digital competency training for teachers, and the integration of digital media that is relevant to the learning styles of the younger generation. By utilizing existing opportunities, Arabic language learning can be more contextual, interesting, and effective for today's generation
Abstract:The purpose of this research is to find out how the EFL Students' perceptions of using AI Paraphrasing Tool and the factors influencing the EFL Students' perceptions of using AI Paraphrasing Tool in Academic English Writing…
ing Class at the Eighth Semester of English Language Education Study Program South Tapanuli Education Institute . The informants of this research consist of 15 students. The researcher uses purposive sampling technique to get the subjects or informants. The data was obtained by distributing the questionnaire and interviewing for the informants. It is found that the result of the EFL Student's perceptions of using AI Paraphrasing Tool in Academic English Writing Class at the Eighth semester of the English Language Education Study Program of the South Tapanuli Education Institute is positive category. The researcher found that the mean score of Strongly Disagree categories (10.3%), Disagree (18%), Neutral (29%) and Agree (20.3%), Strongly Agree (22.3%). Furthermore, the result of factors influencing the EFL Students' perceptions of using AI Paraphrasing Tool in Academic English Writing Class in Academic English Writing Class at the Eighth semester of English Language Education Study Program South Tapanuli Education Institute is external factors more dominant than internal factors. A part of seven factors (Smith (1945), in this study, during the interview process, researchers found that there were other factors that influenced students in making decisions about using AI Paraphrasing Tool, it is a factor of cost.
Abstract:The transformation of Indonesia's education system faces significant challenges in aligning with the demands of globalization, digitalization, and lifelong learning. These challenges have sparked debates regarding the effectiveness…
fectiveness of the full-day school model and the modular education system. This study aims to comparatively analyze these two approaches within the context of primary and secondary education in Indonesia, referencing modular education practices in the United Kingdom as an international benchmark. The study employs a qualitative approach based on a literature review, utilizing thematic content analysis of 20 accredited scholarly sources selected through strict inclusion criteria, and analyzed with the assistance of NVivo software to ensure thematic accuracy.The findings indicate that the full-day school model excels in fostering discipline and consistent learning structures; however, it poses risks of cognitive fatigue and is less supportive of differentiated instruction. In contrast, the modular system offers flexibility, opportunities for personalized learning, and deeper conceptual understanding, yet requires adequate digital infrastructure and self-directed learning literacy, which are not evenly distributed.The study concludes that no single educational model is universally superior; instead, each holds contextual relevance. This research contributes theoretically by enriching the comparative education literature and practically by informing the design of more adaptive, inclusive, and responsive learning policies to meet the challenges of the 21st century, while also supporting efforts to achieve quality education as outlined in the Sustainable Development Goals (SDGs).
Abstract:This study aims to review the mortgage lending process in a bank, focusing on procedures, requirements, and challenges faced by both the bank and customers. The research background is based on the author's internship experience…
erience at the bank, providing an opportunity to gain in-depth insights into the mortgage approval mechanism from a practical perspective. This study employs a qualitative method, utilizing interviews with bank employees involved in the mortgage application process and literature studies related to banking policies. The findings reveal that mortgage approval involves a comprehensive evaluation of the borrower's financial capability, including credit analysis and compliance with banking regulations. Additionally, several challenges were identified, such as the lengthy administrative process and credit risk factors that the bank must consider. The conclusion of this study emphasizes that mortgage lending requires a balance between the bank's interests and customer needs, necessitating innovations in procedures and service optimization to improve process efficiency.
Abstract:This study delves into the significant impact of Quranic verses on fostering mental and spiritual health, focusing particularly on enhancing soul tranquility through spiritual therapy. In the face of rising mental health…
issues such as stress, anxiety, and depression, incorporating spiritual dimensions within psychotherapy has proven to be essential. Utilizing a comprehensive literature review methodology, this research scrutinized various academic sources to evaluate the effectiveness of integrating Quranic verses in contemporary psychotherapy practices. The findings reveal that embedding spiritual elements notably promotes soul tranquility, reduces stress symptoms, and improves overall life quality. This underscores the Quran's pivotal role in supporting both psychological therapy and spiritual well-being, validating the verses' utility as therapeutic tools. The study suggests that future research should expand on the exploration of these spiritual practices in varied clinical settings to further confirm their benefits in enhancing mental health. The inclusion of spiritual values in clinical practice not only aids in mental health recovery but also meets modern therapeutic demands, providing a holistic approach to maintaining mental and soul tranquility.
Abstract:This article examines the transformation of the meaning of the Quran in the context of death rites and death commemorations in Javanese society, especially in Central Java and Yogyakarta, during the period 2000–2023. This…
his research approach is qualitative by utilizing ethnographic data, archival studies, ritual documentation, and in-depth interviews with ritual practitioners. The use of the Quran, which was originally a sacred Islamic text with normative content, has undergone a transformation of meaning when adapted into traditional Javanese rites. The process of cultural acculturation that occurred illustrates the dynamics between ancestral traditions and Islamic values, which provide space for the reinterpretation of religious symbols by local communities (Anderson, 2003; Suryadi, 2011). The historical analysis method and the theory of cultural transformation proposed by Clifford Geertz are used to explain the evolution of the use of the sacred text and highlight the role of ritual as a medium for negotiating meaning between cultures. The results of the study show that the insertion of Quranic verses into Javanese mantras not only functions as a sacred element, but also as a tool for social legitimacy and cultural identity of the Javanese people. This finding opens up opportunities for further study on the integrative role of ritual in shaping religious and cultural identity in Indonesia.
Abstract:Family communication plays a fundamental role in shaping an individual's character, particularly in adulthood. This study examines the influence of family communication patterns on adult character formation through a bibliometric…
liometric analysis. Utilizing a Systematic Literature Review (SLR) and bibliometric approach, this research explores key trends, theoretical frameworks, and scholarly discussions related to family communication and character development. The study highlights the significance of open, trust-based, and emotionally supportive communication in fostering essential adult traits such as responsibility, integrity, empathy, and adaptability. Findings suggest that families with high conversation orientation cultivate individuals with stronger social skills and problem-solving abilities, whereas rigid conformity-oriented communication may hinder independent decision-making. Additionally, digital communication emerges as a growing factor influencing family dynamics. By mapping research trends and analyzing citation patterns, this study provides valuable insights into the long-term impact of family communication on adulthood and offers recommendations for future research.
Abstract:The processing of fisheries products, characterized by the diversification of processed goods, presents a promising avenue for entrepreneurial endeavors. Product diversification holds the potential to augment the intrinsic…
ic value of products and concurrently elevate public consumption of fisheries-related commodities. This research aims to analyze the prospective added value stemming from the pempek businesses in Melayu Sub-District, Tenggarong, Kutai Kertanegara. The acquired data underwent meticulous processing, tabulation, and subsequent analytical examination, characterized by both descriptive and value-added analyses, utilizing the Hayami model. The research showed that the managed pempek businesses are predominantly of small scale, utilizing relatively simple technology. On average, a single production cycle yields 126.64 kg, or monthly output of 633.2 kg. The value-added analysis reveals a figure of 186,734 IDR per kg, with a commendable value-added ratio of 70.95%. This signifies that the conversion of belida fish into pempek not only imparts substantial value but also presents a highly promising avenue for further expansion and development.