Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:This study aims to examine the effectiveness of the Rally Table strategy in improving students’ English writing skills at the junior high school level. The research employed a quasi-experimental design with a pre-test and…
and post-test non-equivalent control group design. The participants consisted of eighth-grade students from MTsS Al-Qosimiyah Sorek Satu, divided into experimental and control groups. The experimental group received writing instruction using the Rally Table strategy, a cooperative learning technique where students take turns contributing to a written task collaboratively. In contrast, the control group received conventional teaching methods. Data were collected through writing tests and analyzed using statistical methods to determine the significance of the improvement. The results indicated that students in the experimental group showed a significantly higher improvement in writing performance compared to those in the control group. These findings suggest that the Rally Table strategy can effectively enhance students’ ability to generate ideas, organize content, and use grammar and vocabulary appropriately in writing. It is recommended that English teachers integrate cooperative learning strategies such as Rally Table into their writing instruction to foster active participation and improve writing outcomes.
Abstract:Background: Preschool-Aged children, aged 3–6 years, where the preschool period becomes a very fun time and get various new things. The weakness experienced by preschool children is that their immune system is weaker than…
han adults, which makes them more susceptible to infections, as well as the risk of falls and injuries, so they require medical treatment in the hospital. Childern who undergoing treatment at the Puskesmas can cause anxiety for them because they must leave their familiar, safe, loving, and enjoyable home environment. Hospitalization is a planned medical procedure that requires care and treatment but can trigger anxiety in children, both mentally and physically. Anxiety will cause children to become uncooperative and difficult to cooperate with health workers. During this process, children may face traumatic experiences that cause stress. One of the efforts to reduce the level of anxiety is by implementing play therapy, one of which is the coloring play therapy technique. Objective: This research describes the application of coloring play therapy on anxiety levels in preschool-aged children at Padamara Health Center. Methods: This research used a case study research design method. Results: This research indicate that before the intervention score was 25 (moderate anxiety) and after the intervention score was 9 (no anxiety). Conclusion: Coloring play therapy can reduce anxiety levels in preschool-aged children undergoing treatment at Padamara Health Center.
Abstract:Background: Anemia is a condition in which the level of red blood cells or hemoglobin in the body is below normal. In pregnant women, anemia can pose health risks to both the mother and the fetus. One of the non-pharmacological…
logical treatments that can be used is the administration of natural ingredients such as beetroot, which serves as an alternative due to its content of iron, folic acid, and vitamin C that can help increase hemoglobin levels. Objective: To provide an overview of the implementation of beetroot juice to increase hemoglobin levels in pregnant women with anemia. Methods: This study used a case study design involving one pregnant woman with anemia who met the inclusion criteria. The intervention consisted of administering 200 ml of beetroot juice per day for seven consecutive days. Evaluation was carried out by measuring hemoglobin levels before and after the intervention using the Easy Touch GCHb device. Results: The results showed that hemoglobin levels increased from 10.5 g/dL before the intervention to 11.8 g/dL after seven days, with an increase of 1.3 g/dL. Conclusion: Regular administration of beetroot juice is effective in increasing hemoglobin levels in pregnant women with anemia.
Abstract:Background: Diabetic ulcers are a chronic complication frequently experienced by individuals with diabetes mellitus and significantly contribute to morbidity, mortality, and lower extremity amputation rates. Effective wound…
und management is key to preventing further complications. Modern dressings based on the moist wound healing principle have been proven more effective than conventional methods, as they maintain wound moisture and support tissue regeneration. Objective: To describe the treatment of diabetic ulcers using the modern dressing method with red fruit (Pandanus conoideus Lamk) ointment in Gelang Village, Rakit District. Methods : This study used a descriptive case study approach involving one diabetic ulcer patient who met the inclusion criteria. Wound care was performed every two days for 14 days using modern dressing and red fruit ointment. Data were collected through observation, interviews, and documentation. Results: There was an improvement in wound conditions after the application of red fruit ointment, marked by an increase in granulation tissue and a decrease in necrotic tissue. The active ingredients in the ointment such as β-carotene, tocopherol, oleic acid, and linoleic acid have antioxidant and anti-inflammatory effects that accelerate the healing process. Conclusion: Modern dressing with red fruit ointment is effective in accelerating the healing process of diabetic ulcers and can serve as an alternative topical therapy to support optimal wound recovery
Abstract:Background: Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion. One effort to help lower blood glucose levels is…
s through complementary therapy using natural ingredients such as tomato juice and dragon fruit juice, which contain various active compounds such as lycopene, fiber, vitamin C, and antioxidants.Objective: To determine the effect of tomato juice and dragon fruit juice on 2-hour post prandial blood glucose levels in type 2 diabetes mellitus patients. Methods: This research is a case study with two subjects who met the inclusion criteria. The intervention was administered for 7 days, during which subjects consumed tomato juice and dragon fruit juice. Blood glucose levels were measured before and after the intervention using an Easy Touch device. Results: The study showed a decrease in blood glucose levels after administration of both juices. This indicates that the combination of tomato juice and dragon fruit juice can significantly lower blood glucose levels. Conclusion: Administering tomato juice and dragon fruit juice can be an effective complementary therapy in lowering blood glucose levels in patients with type 2 diabetes mellitus.
Abstract:This study aims to analyze the application of spiritual quality in cupping and ruqyah services and identify strategies for improving spiritual quality implemented at the Soreang Branch of the Bekam Ruqyah Center. The problems…
blems identified were customer dissatisfaction related to limited service space and a less than optimal religious atmosphere that affected comfort during therapy. This study used a descriptive qualitative approach with data collection techniques through in-depth interviews, participant observation, and documentation. While data validity was strengthened by triangulation of sources, methods, and theories with the help of NVivo 12 software and supplemented with a SWOT analysis. The results showed that the implementation of spiritual quality improvement was carried out by the presence of Islamic values, maintaining cleanliness, reciting prayers, and the therapist's empathetic attitude were important factors in fostering a sense of calm and comfort in customers. Implementing strategies for improving spiritual quality through therapist training, implementing SOPs based on Islamic law, and creating a supportive spiritual environment. However, limited service facilities and infrastructure still need to be addressed for improvement. Therefore, this study as a whole confirms that service quality that connects spiritual and physical aspects holistically contributes significantly to customer satisfaction.
Abstract:The development of digital technology brings both challenges and opportunities for families in managing household finances. Low financial literacy and limited use of technology have caused some families to struggle in achieving…
hieving financial independence. This community service activity aims to enhance family financial independence through socialization, digital financial literacy training, and technology-based business mentoring. The implementation methods include problem identification, delivery of financial literacy materials, practical use of digital financial applications, and online entrepreneurship assistance. The results show an increase in families’ knowledge of budgeting, saving, and utilizing digital platforms to generate additional income. Thus, this program contributes to the creation of more financially independent families in the digital era.
Abstract:This study aims to determine the effect of using atlas teaching aids on students’ learning interest in Social Studies (IPS) subject in Grade V at MI Miftah Assa’adah, South Tangerang. The research method used is an experimental…
xperimental method with a Nonequivalent Control Group Design. The research subjects consisted of two classes: a control class that used conventional teaching methods, and an experimental class that used atlas teaching aids during the learning process. The results of the study showed that the control class obtained an average final score of 52.13, while the experimental class obtained an average final score of 59.04. An independent t-test on the post-test data showed a significance value (2-tailed) of 0.001 < 0.005, which means there is a significant difference in students’ learning interest between those who used atlas teaching aids and those who were taught using conventional methods. Therefore, it can be concluded that the use of atlas teaching aids has a positive and significant effect on increasing students’ learning interest in the Social Studies subject in Grade V at MI Miftah Assa’adah, South Tangerang.
Abstract:Background: The Family Planning Program (KB) is a government effort to control population growth in Indonesia. One of the contraceptive methods that is highly recommended in the KB program is the intra uterine device (IUD)…
D) or often called a spiral. IUD is a contraceptive that can be used in the long term with high effectiveness in preventing pregnancy, while having minimal risk of side effects if used correctly, but the number of IUD usage in Indonesia is still relatively low compared to other contraceptive methods. Research Objective: To determine the effect of knowledge and attitude on the interest of mothers in using IUD KB at the Wanayasa Health Center. Method: This study used a quantitative method with a sample of 66 respondents. Data analysis was carried out using bivariate and univariate, significance was determined if (p value <0.05). data processing was carried out using SPSS. Result: The results of the study showed that in the knowledge variable there were 37 respondents with good knowledge, 23 respondents with sufficient knowledge and 6 respondents with less knowledge. As for the attitude variable, there were 52 respondents with positive attitudes and 14 respondents with negative attitudes. The results of this study also show that there is an influence between knowledge and interest in mothers using IUD with P-Value = 0.003, while the attitude variable also shows that there is an influence between attitude and interest in mothers using IUD with P-Value = 0.010. Conclusion: there is a significant influence between knowledge on interest in mothers using IUD and attitude on interest in mothers using IUD