Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:This study examines structural and spatial gaps in Indonesia’s railway network through a comparative analysis with Japan, India, the Philippines, and Uzbekistan, aiming to formulate adaptive, efficient, and sustainable railway…
railway modernization strategies. Using a qualitative descriptive-comparative approach grounded in pragmatism, the research emphasizes the policy relevance of global best practices adapted to Indonesia’s context. Lessons from Japan and India highlight network integration, business diversification, and logistics efficiency, while the Philippines and Uzbekistan demonstrate the importance of adaptive governance, technological innovation, and institutional reform in strengthening interregional connectivity. In Indonesia, modernization should integrate the roles of PT Kereta Api Indonesia (KAI), the Directorate General of Railways, and local governments to enhance connectivity, improve logistics efficiency, and promote equitable regional development. These findings provide a conceptual and managerial reference for designing inclusive, adaptive, and equitable national public transport policies.
Abstract:Gender issues in public spaces and Muslim communities have increasingly gained attention in academic discourse due to their strong connection with social norms, cultural values, and religious interpretations that shape women's…
omen's patterns of participation. This study aims to examine the influence of gender norms and values within Muslim communities on women’s engagement in public spaces, uncover the challenges they face, and formulate recommendations based on feminist and social constructionist perspectives to promote gender equality. The research employs a Systematic Literature Review (SLR) method by tracing reputable academic databases through rigorous selection and thematic analysis. The findings reveal that Muslim women’s participation in public spaces is often hindered by patriarchal constructions, discrimination, and limited access. Nevertheless, women have developed strategies of resistance and negotiation that expand their roles. Thematic analysis identifies three main patterns: women’s representation in public spaces, gender-based social practices that impose limitations, and resistance strategies through religious reinterpretation and community activism. This article contributes to theoretical development by enriching global feminist perspectives through the lived experiences of Muslim women while also offering practical contributions in the form of inclusive and socially–religiously sensitive public policy recommendations. The implications highlight the importance of cross-cultural studies and the exploration of women’s experiences at the local community level to broaden understanding of gender equality in contemporary Muslim societies.
Abstract:Nurses, as the frontline of healthcare services, are expected to deliver optimal performance that frequently goes beyond their formal duties, thus requiring robust psychological capital to support voluntary work behaviors…
s known as Organizational Citizenship Behavior (OCB). This study aims to analyze the effect of Psychological Capital (PsyCap), which comprises hope, efficacy, resilience, and optimism, on nurses' OCB in regional hospitals and to identify the most dominant dimension influencing OCB. Employing a quantitative correlational approach, this research collected primary data through structured questionnaires distributed to nurses as respondents. The data were analyzed using descriptive statistics, multiple regression analysis, and moderated regression analysis to test variable relationships and the moderating effects of demographic factors. The results indicate that the levels of PsyCap and OCB among nurses are relatively high, with resilience emerging as the most significant predictor of OCB. These findings strengthen the position of PsyCap as an essential psychological resource that fosters prosocial behaviors among nurses, especially in regional hospitals often challenged by limited human resources. The implications suggest that hospital management should design PsyCap enhancement programs, focusing particularly on strengthening nurses' mental resilience to sustainably improve healthcare service quality. This study also contributes theoretically by enriching the literature on organizational behavior within the Indonesian healthcare sector.
Abstract:This study aims to analyze the influence of Transformational Leadership, Work Climate, and Skill Variety on the effectiveness of teacher work teams at Integrated Islamic Junior High Schools in the Riau Islands Province.…
The research uses a quantitative approach with a survey method. The sample consists of 120 teachers selected through proportional stratified random sampling. The research instrument is a Likert-scale questionnaire that has been tested for validity and reliability. Data analysis was carried out using Spearman correlation tests and non-parametric regression with the aid of SPSS version 29.00. The results show that all independent variables are positively and significantly related to teacher work team effectiveness (Transformational Leadership: ρ = 0.757; Work Climate: ρ = 0.795; Skill Variety: ρ = 0.767; p < 0.05). Non-parametric regression testing indicates a significant simultaneous effect (ρ = 0.000). Partially, Transformational Leadership (p = 0.253; p = 0.000), Work Climate (ρ = 0.355; p = 0.000), and Skill Variety (ρ = 0.282; p = 0.000) significantly influence teacher work team effectiveness. Work climate is proven to be the dominant factor affecting team effectiveness. The implications of this study affirm that improving teacher work team effectiveness must be carried out holistically through strengthening school principals’ transformational leadership, creating a conducive work climate, and developing teachers’ skill variety.
Abstract:Penelitian ini menyoroti krisis integritas kepemimpinan yang melanda Indonesia dan gereja, yang kerap dipengaruhi oleh adopsi model kepemimpinan sekuler yang pragmatis serta mengabaikan spiritualitas Alkitabiah. Walaupun…
keteladanan Yesus menjadi acuan utama, kajian teologis khusus tentang integritas spiritual kepemimpinan-Nya dalam Injil Matius masih terbatas. Tujuan penelitian ini adalah mendeskripsikan dan menganalisis integritas spiritual Yesus dalam Injil Matius serta menggali implikasinya bagi kepemimpinan Kristen di Indonesia, khususnya bagi guru Pendidikan Agama Kristen dan pemimpin gereja. Penelitian menggunakan metode kualitatif deskriptif dengan studi literatur serta eksegesis historis-gramatikal dan teologis terhadap Injil Matius. Hasil penelitian mendefinisikan integritas secara holistik sebagai kesatuan identitas diri, keaslian hidup, keberanian moral, kedekatan dengan Allah, dan kompetensi praktis. Integritas ini berakar pada relasi dengan Allah dan menuntut keselarasan antara perkataan, tindakan, serta kehendak-Nya. Kepemimpinan Kristen dipahami bukan sekadar kapasitas manusiawi atau posisi, melainkan panggilan ilahi yang menuntut visi rohani, integritas, dan pelayanan kasih. Empat kualifikasi integritas kepemimpinan Yesus yang ditemukan adalah: (1) Kepemimpinan melalui kehidupan doa yang tekun sebagai dasar ketergantungan total pada Allah dan ketaatan kepada kehendak-Nya; (2) Kepemimpinan sesuai tuntunan Roh Kudus sebagai sumber wibawa dan kuasa yang bersumber dari pengurapan ilahi; (3) kepemimpinan berdasarkan kebenaran firman Tuhan sebagai otoritas tertinggi, sumber kebenaran, inspirasi, hikmat, dan pendoman kehidpan; dan (4) kepemimpinan berkarakter ilahi yang nyata melalui kasih agape, kerendahan hati, belas kasihan, kejujuran, ketulusan, serta penolakan terhadap kemunafikan. Kesimpulannya, integritas kerohanian merupakan pilar fundamental yang menyatukan kedalaman spiritualitas dengan kredibilitas praktis, sekaligus memberikan kerangka teologis yang kokoh untuk membangun kepemimpinan Kristen yang otentik dan transformatif di tengah krisis integritas.
Abstract:This article examines in depth the relationship between the Qur'an and the concept of diversity in the context of modern society. By using a qualitative approach and content analysis of Qur'anic verses that touch on the…
issue of ethnic, religious, and racial differences, this study seeks to uncover the universal and contextual dimensions of the principles of diversity in Islamic teachings. Gadamer's hermeneutic approach is used as a theoretical framework for critically interpreting Qur'anic texts, with the aim of contributing to the treasure trove of modern interpretations of pluralism. The findings of the study show that the Qur'an, through verses that emphasize the unity of humanity and respect for diversity, provides a strong foundation for the implementation of diversity values. The discussion also explained the social implications of the application of the principle of diversity according to the Qur'an, including in the context of politics, education, and intercultural relations in pluralistic societies. By integrating critical analysis of sacred texts with empirical data and theoretical studies, this article is expected to make a significant contribution to the research treasure trove of Islamic studies and pluralism. This research emphasizes that the role of the Qur'an in upholding the value of diversity is multi-perspective; It not only provides spiritual guidance, but also offers an ethical framework that can foster the construction of an inclusive, just, and harmonious modern society. The purpose of this research is to elaborate on the role of the Qur'an as a source of values of diversity and pluralism, by tracing relevant verses and relating them to the social reality on the ground. Thus, this research not only aims to provide textual analysis, but also examines the practical application of the teachings of the Qur'an in promoting peace and social justice in the era of globalization. This research is expected to be an important reference for researchers and academics of Islamic studies and pluralism in an effort to strengthen interfaith dialogue and increase tolerance and social justice.
Abstract:This study examines the concept of social solidarity and religious values, especially those contained in the Qur'an. Social solidarity has long been the focus of discussion in various disciplines, ranging from sociology,…
political science, to Islamic studies. In the midst of the increasingly complex dynamics of urbanization in Indonesia, the question of how religious values, especially those contained in the Qur'an, can encourage collective action based on social justice is very relevant. By examining in depth the relationship between the teachings of the Qur'an and social solidarity, this article contributes to the development of social theory and practice in urban Indonesian society. It is hoped that the findings and recommendations presented can be a reference for academics, researchers, and policymakers in formulating strategies for integrating Islamic values into contemporary social dynamics, so that in the end it can produce a more just, inclusive, and dignified society. The results of the study show that there is a strong integration between the theological message in the Qur'an and the dynamics of social interaction, as well as its implications in the formation of pro-people public policy. Thus, the conceptual framework proposed in this study not only makes a theoretical contribution to the development of Islamic studies and sociology, but also offers practical recommendations that are applicable to the strengthening of social solidarity in the modern era. This study suggests that further studies can explore more empirical aspects, involving field data and participatory analysis, to ensure that the values of the Qur'an are truly integrated into social life and public policy as a whole. This research invites further dialogue between stakeholders in an effort to realize solid social solidarity, as a tangible manifestation of the application of the principles of goodness and justice enshrined in the Qur'an.
Abstract:The integration of artificial intelligence (AI) in patent systems has emerged as a complex area in intellectual property law. This systematic literature review follows PRISMA 2020 guidelines to analyze AI implementation…
in patent systems, particularly within the Indonesian context. The study examines 11 key studies published between 2015-2025 through systematic searches across multiple academic databases. Results demonstrate that AI implementation has achieved significant improvements in operational efficiency, particularly in automated patent classification, prior art searching, and examination support systems. Approximately 190,000 AI patents were granted globally between 2000-2022, reflecting increasing technological importance. In Indonesia, AI implementation must align with Law No. 13 of 2016 on Patents as amended by Law No. 65 of 2024. The landmark Thaler v. Vidal case confirms AI cannot be an "inventor" but can serve as an assistive tool with significant human contribution. Key challenges include AI decision-making transparency and knowledge gaps among patent examiners.
Abstract:The growth of the cosmetics industry in Indonesia is influenced by the increasing demand for beauty products. One of the contributing factors to this trend is a common issue faced by women, especially Gen Z, which is dull…
l skin. One of the most purchased beauty products by Gen Z is facial serum. The aim of this research is to examine the influence of Negative EWOM (Electronic Word of Mouth) and variety seeking on brand switching behavior, with customer engagement as an intervening variable for Scarlett facial serum among Gen Z consumers. This study employs a quantitative approach with descriptive and causal research methods. Data collection is done through a questionnaire survey with 300 respondents who use Scarlett facial serum in Indonesia. The data analysis technique used is Structural Equation Modeling (SEM) using SmartPLS for research data analysis. The research findings indicate that Negative EWOM have a positive influence on brand switching behavior, Negative EWOM have a negative influence on customer engagement, variety seeking have a negative influence on customer engagement, variety seeking have a positive influence on brand switching behavior, customer engagement have a negative influence on brand switching behavior, Variety seeking on brand switching behavior through customer engagement as an intervening variable have a positive influence, Negative E-WOM on brand switching behavior through customer engagement as an intervening variable also have a positive influence.This research has implications for companies, including the need for companies to enhance product quality and their brand image in response to Negative E-WOM. Companies should also continue to innovate by improving product quality and uniqueness. Additionally, understanding customer preferences and market trends is crucial for competing in a market with many similar products. Maintaining customer interactions can also keep the company top of mind among customers, preventing them from switching to other brands. These actions are necessary to retain customers and prevent brand switching. Referring to several previous studies, research on negative word of mouth, brand switching behavior, variety seeking, and customer engagement has never been conducted simultaneously with the same variables and object.