Abstract:Antimicrobial resistance has driven the urgent need to develop new antibacterial candidates with favorable efficacy, pharmacokinetic properties, and safety profiles. Aaptamine derivatives, secondary metabolites isolated…
from marine sponges of the genus Aaptos, have demonstrated potential as drug candidates; however, studies evaluating their drug-likeness, Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and toxicity profiles remain limited. This study aimed to prioritize aaptamine, demethyl(oxy)aaptamine, and isoaaptamine as potential antibacterial candidates through SwissADME and ProTox-II analyses using an in silico approach. The results demonstrated that all three compounds satisfied the Lipinski's Rule of Five criteria for drug-likeness, exhibited high gastrointestinal absorption, and achieved a bioavailability score of 0.55. All compounds were predicted to belong to toxicity class 4, with predicted LD₅₀ values of 1300 mg/kg for aaptamine, 500 mg/kg for demethyl(oxy)aaptamine, and 1350 mg/kg for isoaaptamine, while none showed hepatotoxic or cytotoxic properties. The integrated analysis indicated that isoaaptamine exhibited the most balanced drug-likeness, ADME profile, and safety characteristics, making it the highest-priority antibacterial candidate. This study concludes that the integration of SwissADME and ProTox-II provides an effective preliminary approach for screening marine natural product-derived drug candidates. The novelty of this study lies in the integrated application of drug-likeness, ADME, and toxicity analyses to systematically prioritize three aaptamine derivatives, thereby providing a more comprehensive lead compound selection strategy for antibacterial drug discovery.
Abstract:Employee performance is a crucial factor in supporting the success of government organizations in achieving public service objectives. The Department of Education and Culture of Jayapura City continues to face various challenges…
allenges related to work motivation, work discipline, and the work environment, which are presumed to influence employee performance. This study aims to analyze the effects of work motivation, work discipline, and the work environment on employee performance, both partially and simultaneously. The research employed a quantitative approach with an explanatory research design. The study population consisted of 87 employees, all of whom were selected as respondents through a saturated sampling technique. Data were collected using questionnaires and analyzed through multiple linear regression with the assistance of IBM SPSS Statistics. The findings reveal that work motivation has a positive and significant effect on employee performance, with a significance value of 0.002 and a regression coefficient of 0.388. Work discipline also demonstrates a positive and significant effect, with a significance value of 0.002 and a regression coefficient of 0.310. The work environment emerges as the most dominant variable, with a significance value of 0.000, a regression coefficient of 1.238, and a beta coefficient of 0.417. Simultaneously, work motivation, work discipline, and the work environment significantly influence employee performance, as indicated by an F-statistic of 40.438 and a significance value of 0.000. The coefficient of determination (R Square) of 0.594 indicates that 59.4% of the variation in employee performance can be explained by these three variables. The novelty of this study lies in its empirical evidence that the work environment constitutes the most dominant factor affecting employee performance within the Department of Education and Culture of Jayapura City, an institution characterized by distinctive organizational features and service-area conditions.
Abstract:The advancement of digital technology has encouraged the adoption of e-counseling as an integral component of guidance and counseling services in schools. While the use of digital-based services enhances accessibility and…
d flexibility, it also presents various ethical challenges and professional demands for school counselors. This study aims to identify the ethical challenges associated with school-based e-counseling, analyze the professional considerations required of counselors, and examine the interrelationship among ethics, professionalism, and institutional support in the implementation of e-counseling services. The study employed a Systematic Literature Review (SLR) method guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework through a comprehensive search of articles indexed in Google Scholar, GARUDA, ERIC, Scopus, and ProQuest published between 2015 and 2025. The findings reveal that the primary challenges of e-counseling include data confidentiality, client privacy, digital information security, professional boundaries, and limitations in nonverbal communication. The results further indicate that digital competence, adherence to professional ethical standards, and institutional support from schools are critical factors influencing the effectiveness of e-counseling services. This study contributes a conceptual synthesis that positions ethics, counselors’ digital professionalism, and institutional governance as three interrelated pillars essential for the development of safe, ethical, and professional e-counseling practices within school settings.
Abstract:Contemporary congregational spirituality faces significant challenges due to the rise of individualism, competition, and self-centered orientations that hinder the practice of humility, service, and unity among believers.…
. This condition highlights the importance of a strong theological foundation for cultivating Christ-centered spirituality. This study aims to examine the concept of the ethics of the cross in Philippians 2:5–11 from the perspective of Pauline Christology, identify the ethical values embedded within the passage, and explain their implications for congregational spiritual formation. The study employs a qualitative method with a theological-expository approach through library research and exegetical analysis of Philippians 2:5–11. The findings reveal that the ethics of the cross is rooted in Christ’s self-emptying, His taking the form of a servant, His obedience unto death on the cross, and His subsequent exaltation by God. This ethical framework is expressed through three principal values: relinquishing personal rights and privileges, serving with humility, and demonstrating complete obedience to the will of God. The findings further indicate that congregational spiritual formation should be centered on the transformation of the mind, a life characterized by service, and communal relationships that reflect the character of Christ. The novelty of this study lies in its formulation of the ethics of the cross as a systematic and Christ-centered model of spiritual formation that bridges Pauline Christology and the spiritual development of contemporary congregations.
Abstract:The phenomenon of infidelity within families constitutes a significant social issue, as it not only undermines spousal relationships but also leaves enduring psychological wounds on children who witness it, particularly…
women entering early adulthood when they begin to establish romantic relationships. This study focuses on how early adult women interpret their experiences of witnessing paternal infidelity and the implications of these experiences for trust, commitment, emotional dynamics, and partner selection processes. A qualitative approach with a phenomenological design was employed to explore the subjective experiences of three early adult women aged 20-22 who encountered such events during adolescence. The findings indicate that these experiences are interpreted as traumatic, giving rise to anxiety, fear of betrayal, and difficulties in developing trust, while simultaneously fostering heightened vigilance and selectivity in choosing partners, with an emphasis on loyalty, communication, and emotional security. The emerging psychological dynamics include trust issues, a tendency to avoid conflict, and a strong need for emotional stability, which are addressed through conscious efforts to build healthier relationships characterized by open communication and effective emotional regulation. The study concludes that the subjective meaning-making of paternal infidelity plays a crucial role in shaping relational patterns, perceptions of romantic relationships, and partner selection decisions among early adult women. The novelty of this research lies in its emphasis on the meaning-making dimension, which not only reveals psychological impacts but also highlights resilience and the transformation of traumatic experiences into a foundation for more adaptive and constructive relationships.
Abstract:The management of volleyball training sessions among collegiate athletes faces complex challenges due to the lack of integrated scientific approaches, which may reduce training effectiveness and increase the risk of fatigue…
gue and injury. This study addresses the suboptimal implementation of periodization-based microcycle planning, training load monitoring, and recovery strategies within a unified system. The objective of this research is to examine the effectiveness of an integrated training management model in improving athletes’ performance and physiological condition. A quasi-experimental method with a pretest–posttest control group design was employed, involving 40 collegiate athletes over an eight-week period. The results indicate that the experimental group showed significant improvements in countermovement jump by 12.2% and spike reach by 3.1%, accompanied by a reduction in sRPE by 11.5% and an increase in recovery scores by 22.5%, while the control group demonstrated no meaningful changes. These findings suggest that the integration of microcycle planning, internal and external load monitoring, and structured recovery strategies enhances physiological efficiency, neuromuscular adaptation, and the sustainability of athletic performance. The study concludes that the integrated training management model is more effective than conventional approaches as it enables objective and systematic control of training intensity. The novelty of this research lies in the development of an integrated training session management model that combines three key components in an applicable, practical, and context-appropriate manner for collegiate athletes, thereby bridging the gap between sport science theory and coaching practice.
Abstract:Chronic pain represents a major global health burden and often remains resistant to conventional pharmacological treatment, prompting the exploration of alternative therapeutic strategies. Electroencephalographic (EEG) neurofeedback…
eurofeedback has emerged as a non-invasive neuromodulatory intervention that enables patients to self-regulate brain activity and potentially alleviate persistent pain symptoms. This systematic review addresses the research problem of inconsistent evidence regarding the clinical efficacy and underlying mechanisms of EEG-based neurofeedback for chronic pain management in adults. A comprehensive analysis of 80 studies involving adults with chronic pain lasting at least three months was conducted, examining neurofeedback protocols, clinical pain outcomes, neurophysiological changes, secondary benefits, and methodological quality. Findings revealed heterogeneous results, with several studies reporting statistically significant and clinically meaningful pain reduction, particularly in conditions such as chemotherapy-induced neuropathy, fibromyalgia, and chronic back pain. Observed neurophysiological changes, including increased alpha power and modified connectivity in pain-related brain regions, were sometimes associated with clinical improvement, alongside reported benefits in sleep quality, mood, and overall well-being. However, evidence from sham-controlled randomized trials showed no significant differences between intervention and control groups, highlighting methodological limitations and challenges in blinding procedures. The review concludes that EEG neurofeedback is a safe and feasible intervention with potential therapeutic value for chronic pain, although current evidence remains inconsistent. The novelty of this study lies in its integrative evaluation of clinical outcomes, neurophysiological mechanisms, and protocol-specific effects, while emphasizing the need for personalized approaches, biomarker identification, and rigorous experimental designs to clarify efficacy and optimize treatment implementation.
Abstract:Population growth that continues to increase has generated various social and health problems due to the imbalance between population size and the quality of human resources. This condition encourages the government to strengthen…
trengthen the implementation of the Family Planning Program as a strategic effort to control fertility among couples of reproductive age. The success of this program is influenced not only by access to health services but also by family support, particularly the husband’s support in decisions related to contraceptive use. This study aimed to analyze the relationship between husband’s support and the decision to use three-month injectable contraception among family planning acceptors. The research applied a quantitative approach with a correlational design and a cross-sectional research type. The population consisted of all family planning acceptors at TPMB Ny. Sofi Rufiah totaling 109 individuals, while the sample included 86 respondents selected through a random sampling technique. Data were collected using a structured questionnaire and analyzed statistically using the Chi-Square test through SPSS software. The results showed that the majority of respondents received support from their husbands, totaling 60 individuals (69.8%), while the use of three-month injectable contraception was reported by 49 respondents (57%). Statistical analysis indicated a significant relationship between husband’s support and the decision to use three-month injectable contraception with a significance value of p < 0.05, meaning the research hypothesis was accepted. These findings confirm that husband’s support is an important factor influencing women’s decisions in selecting contraceptive methods. The novelty of this study lies in emphasizing the role of husband’s support as a social determinant contributing to the successful use of three-month injectable contraception at the level of independent midwifery practice services. The results are expected to provide a foundation for strengthening family-based family planning education strategies.
Abstract:The phenomenon of increasing consumption of homoromantic fiction content among early adult women has given rise to the term Fujoshi, which is often directly associated with support for LGBT issues, although such an interpretation…
pretation does not necessarily reflect individuals’ attitudes in a comprehensive manner. This study is grounded in the need to understand the attitudes of early adult Fujoshi in a more nuanced and non-simplistic way, particularly through the framework of attitude theory encompassing cognitive, affective, and conative dimensions. The research problem focuses on how Fujoshi aged 18-40 interpret, experience, and express their attitudes toward homoromantic fiction content and its relationship to social values and norms in real life. This study employed a descriptive qualitative approach using in-depth interviews with three Fujoshi informants who are members of the XX fan chat group. The findings indicate that social media and peer networks play a significant role in the process of becoming a Fujoshi, as well as in shaping relatively intensive and repetitive patterns of content consumption as a form of emotional entertainment. Cognitively, the informants recognize that homoromantic fiction is related to LGBT issues; however, at the affective level, their interest is primarily driven by the uniqueness of the narrative structure and character dynamics rather than by sexual orientation itself. In the conative dimension, most informants do not demonstrate a tendency to support LGBT practices in real life; some even hold conservative views and display critical awareness of the potential negative impacts of their hobby, which they perceive as not fully aligned with prevailing social norms. The study concludes that Fujoshi attitudes are complex, ambivalent, and highly contextual. The novelty of this research lies in revealing a clear differentiation between the consumption of homoromantic fiction as a form of symbolic entertainment and individuals’ value positions toward social reality, which are often normatively conflated in previous assumptions.
Abstract:The rapid advancement of digital technology and the increasingly widespread penetration of the internet have significantly driven the growth of e-commerce in Indonesia, leading to notable changes in consumer behavior in…
making purchasing decisions. This condition requires business actors to comprehensively understand marketing factors that play a crucial role in influencing consumer decisions on e-commerce platforms, particularly those related to price, promotion, and product quality. The research problem of this study focuses on how these three variables shape consumer purchasing decisions amid increasingly intense e-commerce competition. This study aims to analyze the influence of price, promotion, and product quality on purchasing decisions in e-commerce by employing a qualitative approach through a literature review of various relevant scholarly sources, including both national and international journals. The findings indicate that competitive pricing aligned with consumers’ perceived value has a strong influence on attracting purchase intentions, while appropriate, sustainable, and communicative promotional strategies are able to enhance consumer awareness and purchase motivation. On the other hand, product quality is proven to be a key determinant in building trust, satisfaction, and consumer loyalty in online transactions. The conclusion of this study confirms that price, promotion, and product quality simultaneously contribute positively and significantly to e-commerce purchasing decisions. The novelty of this scholarly work lies in its conceptual synthesis that integrates these three variables within the context of Indonesian e-commerce consumer behavior, providing a holistic understanding that can serve as a strategic basis for decision-making among digital business practitioners in the technology-based economic era.