Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:This study aims to determine “The Relationship Between Workload and Work Stress Among Employees at PT Everbright Rantauparapat Branch.” Workload was measured through indicators of targets to be achieved, working conditions,…
itions, use of working time, work standards, and work stress was measured through indicators of task demands, role demands, organizational leadership, and interpersonal demands. The research population consisted of 36 people with a saturated sampling technique. Primary data were obtained from Likert-scale questionnaires. Based on the results of data analysis conducted, it was found that the research data met the normality assumption, as indicated by a significant value of 0.087, meaning that the data were normally distributed. In addition, the results of the linearity test showed a significance value of deviation from linearity of 0.500, which means that the relationship between workload and work stress is linear. Furthermore, the results of the simple linear regression test showed that there was a relationship between workload and work stress with a result of 0.534, meaning that there is a fairly strong relationship between workload and work stress.
Abstract:Electronic Medical Records (EMR) are designed to improve service quality, documentation accuracy, and administrative efficiency, including reimbursement through the Indonesian Case-Based Groups (INA-CBGs). However, incomplete…
plete medical assessments remain a challenge, potentially leading to service gaps and reduced hospital claims. This qualitative descriptive study was conducted at Dharma Yadnya General Hospital, Denpasar, which has fully implemented EMR since 2024. Data were obtained through in-depth interviews with five informants: two medical record officers, the head of the emergency nursing unit, the head of the inpatient nursing unit, and the head of the medical record department. Data analysis used the 3M framework: Man, Method, and Material. From the Man aspect, heavy workloads of doctors and the lack of administrative support staff often caused delays and incomplete documentation. From the Method aspect, although Standard Operating Procedures (SOPs) and system reminders existed, monitoring relied mainly on manual follow-ups via WhatsApp groups, limiting effectiveness. From the Material aspect, the EMR system was user-friendly and supported by weekly vendor maintenance, but occasional network disruptions and insufficient administrative staff still hampered real-time documentation. Incomplete medical assessments in EMR directly affect INA-CBGs claims, especially when comorbidities, complications, or procedures are not recorded, resulting in under-coding and reduced reimbursement. Strengthening human resources, enforcing SOPs, and improving system support are essential to ensure documentation completeness, service quality, and financial sustainability
Abstract:This study proposes a linear regression-based intelligent calibration approach to improve the accuracy of water turbidity sensor readings in an Arduino microcontroller-based embedded system. The primary objective of this…
research is to develop a mathematical model capable of converting analog values from the Analog-to-Digital Converter (ADC) into a numerical representation that reflects the actual water turbidity level in Nephelometric Turbidity Units (NTU). The calibration process was performed using a standard Hanna Turbidity Meter with water samples ranging from 0.56 NTU to 500 NTU. Measurement results demonstrated a strong linear relationship between the ADC value (495–686) and NTU, with an average system accuracy level above 90%. Comparison of sensor measurements with the standard instrument showed an error margin below 5%, confirming the reliability of the linear regression model in compensating for optical sensor nonlinearities.
Abstract:This study aims to implement the work ethics of government employees in providing public services in Tamalate District based on Law Number 25 of 2009 concerning Public Services. This study uses a qualitative method with…
a case study approach in administrative services in Tamalate District. Data were collected through in-depth interviews with government employees and service users, direct observation of the service process, and analysis of relevant documents. The results of the study indicate that the work ethics of government employees in providing public services is still not optimal. Some employees exhibit unprofessional behavior, such as slow service delivery, lack of empathy towards the public, and low transparency in the service process. However, there are also employees who demonstrate positive behavior, such as providing clear and accurate information, and praying friendly and patient in serving the public. This study concludes that improving the work ethics of government employees is essential through public service ethics training programs, strict supervision, and regular evaluation and monitoring of employee performance. This effort is crucial to ensure public services meet the standards of professionalism, transparency, and accountability as mandated by Law Number 25 of 2009. The results of this study are expected to contribute to improving the quality of public services in Tamalate District and serve as a reference for similar research in the future.
Abstract:This study aims to determine and analyze 1) AnalysisofTransactional Leadership Style on Employee Performance at PT. Citra Mulia Perkasa in Kendari City, Southeast Sulawesi and2) Supporting and Inhibiting Factors of Transactional…
actional LeadershipStyleAnalysis on Employee Performance at PT. Citra Mulia PerkasainKendari City, Southeast Sulawesi. This study uses qualitativedescriptive using the concept of interactive data analysis. Informantsin this study consisted of employees of PT. Citra Mulia Perkasa. Withdata collection techniques of observation, interviews anddocumentation. The results of the study indicate that thetransactional leadership style applied by PT. Citra Mulia Perkasahasnot run optimally because the demands of the work arenot comparable to the results obtained by employees, as well astheexistence of a work culture that is not in accordance withtheregulations or standard operating procedures for workers. Thesefindings are expected to improve the regulations in force at PT. CitraMulia Perkasa and become a learning experience for leaderstoimprove their attitudes towards their employees
Abstract:Drug management is a series of pharmaceutical service activities involving aspects of planning, requesting, receiving, storing, distributing, controlling, recording, and reporting drugs. Drug management in CHCs is an important…
ortant aspect because inefficiency will have a negative impact on health services. The purpose of this study was to evaluate drug management at the Camba Community Health Center UPTD so that it can be used as a reference material to improve the quality of drug management. This type of research is a non-experimental descriptive-observational study. The data used are data in the form of reports and documents on drug management at the community health center. The research instrument used an observation sheet with the references used being the Indonesian Minister of Health Regulation No. 74 of 2016 and the Indonesian Ministry of Health 2019 Technical Guidelines for Pharmaceutical Service Standards in CHCs. The results of the study indicate that drug management at the Camba Community Health Center UPTD is based on the Indonesian Minister of Health Regulation No. 74 of 2016 and the Indonesian Ministry of Health 2019 Technical Guidelines for Pharmaceutical Service Standards at CHCs in the planning aspect are included in the good category with a percentage value of 100%, the request aspect is 100% in the good category, the receipt aspect is 100% in the good category, the storage aspect is 87.5% in the good category, the distribution aspect is 66.7% in the sufficient category, the destruction and withdrawal aspect is 100% in the good category, the control aspect is 100% in the good category, the recording and reporting aspect is 100% in the good category. So it can be concluded that drug management at the Camba Community Health Center UPTD in 2024 has met the standards set by the Indonesian Ministry of Health.
Abstract:Laju Sedimentasi Eritrosit (LED) merupakan salah satu pemeriksaan hematologi yang banyak digunakan sebagai indikator nonspesifik untuk mendeteksi peradangan atau penyakit tertentu. Jenis antikoagulan yang digunakan dalam…
sampel darah dapat memengaruhi hasil LED. Penelitian ini bertujuan untuk mengetahui perbedaan nilai LED antara sampel darah vena yang menggunakan antikoagulan Asam Etilendiamintetraasetat (EDTA) dan antikoagulan natrium sitrat 3,8%. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan metode total sampling yang melibatkan 33 responden di Laboratorium Patologi Klinik Politeknik Indonusa Surakarta. LED diukur menggunakan metode Westergren standar, dan data dianalisis menggunakan uji Wilcoxon. Hasil penelitian menunjukkan nilai LED rata-rata pada sampel dengan antikoagulan EDTA adalah 18 mm/jam, sedangkan pada sampel dengan natrium sitrat 3,8% memiliki nilai rata-rata 14 mm/jam. Hasil uji Wilcoxon menunjukkan adanya perbedaan yang bermakna (p = 0,000; p < 0,05), sehingga menunjukkan bahwa jenis antikoagulan berpengaruh secara bermakna terhadap hasil LED. Secara keseluruhan, EDTA cenderung menghasilkan nilai LED yang lebih tinggi dibandingkan dengan natrium sitrat 3,8%. Temuan ini menekankan pentingnya pemilihan antikoagulan dalam pengujian LED dan menekankan perlunya standardisasi dalam praktik laboratorium. Penelitian lebih lanjut direkomendasikan untuk membandingkan antikoagulan lain dan mengevaluasi metode LED otomatis guna mendapatkan wawasan yang lebih komprehensif.
Abstract:Urine alcohol testing plays a vital role in detecting alcohol consumption for clinical and forensic purposes, yet its results may be influenced by pre-analytical factors such as the delay between sample collection and laboratory…
boratory analysis. This study aimed to evaluate the effect of delay time before urine examination on alcohol concentration. An experimental One-Shot Case Study design was conducted involving 44 participants in Denpasar who had consumed alcohol. Alcohol concentration was measured immediately, after a 2-hour delay, and after a 4-hour delay using the Alcohol Urine Rapid Test Dipstick Allchek, and the data were analyzed using the Kruskal-Wallis test. The findings showed that average urine alcohol levels increased numerically after a 2- and 4-hour delay compared to immediate testing; however, this change was not statistically significant (p=0.131). These results confirm that delaying urine alcohol examination up to 4 hours does not significantly alter detectable alcohol concentrations, although prompt testing is still recommended to ensure result accuracy and minimize the risk of false positives. This study provides important insights for the development of standard operating procedures regarding urine alcohol analysis in laboratory practice.
Abstract:The purpose of this study was to describe how structured tasks from the Numbered Heads Together (NHT) cooperative learning model impacted the learning outcomes of grade X students at SMA Negeri 5 Seram Bagian Barat in the…
e 2024–2025 academic year. This study was experimental and only used a control group for the posttest. This study involved 75 students from three classes at SMA Negeri 5 Seram Bagian Barat. Class X2 (experimental class), consisting of 25 students, and class X3 (control class) were included in the randomly selected sample. According to statistical analysis of the data, the control class obtained a score of 65.60 with a standard deviation of 13.25, while the experimental class obtained a score of 75.00 with a standard deviation of 10.40. The completeness of the experimental class was 84.00%, while the control class was 44.00%. Based on the results of the study, the structured task approach influenced the learning outcomes of grade X students of SMA Negeri 5 Seram Bagian Barat on the topic of chemical bonds.