Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:Muhammad Iqbal emerged during a period of intellectual stagnation in the Muslim world in the early 20th century, introducing a fresh and visionary idea: the reconstruction of religious thought. In his seminal work, The Reconstruction…
Reconstruction of Religious Thought in Islam, Iqbal proposed a way out of this stagnation by revitalizing the Islamic intellectual heritage while engaging in a critical dialogue with modernity. This study aims to examine the key concepts of Iqbal's project, including his critique of Greek philosophy, his dynamic view of ijtihad (legal reasoning), his theory of the "Khudi" (Self), his dynamic concept of God and the universe, and his vision of spiritual democracy. Using a qualitative approach with philosophical-hermeneutic analysis, this research concludes that while Iqbal's thought has been widely appreciated as a revitalizing force for Islamic intellectualism, it has also faced criticism concerning its practical implementation and philosophical consistency. The study finds that Iqbal's ideas remain profoundly relevant today, particularly in navigating the challenges of modernity without sacrificing Islamic identity.
Abstract:Menstrual pain, or dysmenorrhea, is a common menstrual disorder experienced by teenage girls that can disrupt daily activities. Menstrual pain management includes, but is not limited to, pharmacological and non-pharmacological…
ogical approaches. One of the non-pharmacological treatments is called acupressure. This study aims to determine the effect of acupressure therapy on the intensity of menstrual pain among female students at SMA Negeri 5 Banda Aceh. The research employed a quantitative design with a one-group pretest and posttest quasi-experimental design. The population consisted of 153 girls, and 20 of them were selected as the sample using a purposive sampling technique. The data were collected using a Numeric Rating Scale (NRS) questionnaire from May 7th to 17th, 2025. Then, the data was analyzed using the Wilcoxon Test, which obtained a p-value of 0.000 <0.05. This result indicated there was an acupressure effect on menstrual pain. Therefore, this finding proved that the use of acupressure influenced menstrual pain among female students at SMA Negeri 5 Banda Aceh. This study recommends that female students familiarize themselves with and practice acupressure techniques as an effort to reduce menstrual pain without relying on medication. Furthermore, female students need to be more open to seeking information and natural solutions for controlling reproductive health at an early age.
Abstract:A fuzzy logic-based control system in household split-type air conditioners (AC) offers an alternative approach to reducing excess energy consumption without compromising thermal comfort. This study aims to test the effectiveness…
ctiveness of three types of membership functions (MF), namely triangular, trapezoidal, and Gaussian, in improving energy efficiency and the stability of room temperature and humidity control. Simulations were performed using MATLAB software with the Mamdani fuzzy inference method and centroid defuzzification technique. The three MF were tested using 30 sets of temperature and humidity data to analyze their effect on fan speed and power consumption. The simulation results show that the trapezoidal MF provides the highest energy efficiency of 57.24%, followed by the Gaussian MF at 56.80% and the triangular MF at 53.71%. These findings indicate that fuzzy systems can significantly reduce energy consumption compared to conventional air conditioner controllers. This research is expected to serve as a reference in the development of more energy-efficient intelligent control systems.
Abstract:This study aimed to identify risk factors associated with hypertension in Bonto Tallasa Village, Uluere Subdistrict, Bantaeng Regency, in 2025. The research examined three factors: family history, excessive sodium intake,…
, and stress. A quantitative case–control design was applied to 60 respondents (30 cases and 30 controls) selected through purposive sampling. The results showed that individuals with a family history of hypertension were about 26 times more likely to develop hypertension than those without such a history, indicating a strong and significant association. Excessive sodium intake increased the risk approximately 3.5 times and was statistically significant. Stress was associated with nearly double the risk, but this association was not statistically significant, possibly due to individual differences in coping mechanisms and measurement limitations of subjective stress levels. This suggests that stress may influence hypertension indirectly through behavioral or physiological pathways. In conclusion, family history and excessive sodium intake are significant predictors of hypertension, while stress contributes to an elevated yet statistically nonsignificant risk. Preventive strategies should emphasize sodium reduction, regular blood pressure monitoring, and effective stress management in daily life.
Abstract:Exposure to X-ray radiation in conventional radiology procedures can pose a health risk, especially for accompanying caregivers of pediatric patients who only bear the risk without gaining any benefit. This study aims to…
determine the estimated equivalent dose received by accompanying caregivers of pediatric patients and the safest points during conventional radiology examinations. The method used in this research is a field survey, involving the measurement of equivalent radiation doses inside and outside the examination room using a personal dosimeter, as well as measuring the radiation dose rate at 6 points using a surveymeter. The data was processed to obtain the highest and lowest values, as well as the percentage of equivalent dose obtained compared to the established Dose Limit Value (DLV). The results showed that the highest radiation dose received by accompanying caregivers inside the examination room reached 13,46 µSv, with a percentage of 0,27% relative to the DLV, while the lowest dose recorded was 1,12 µSv, with a percentage of 0,0224% relative to the DLV. Analysis of the radiation dose rate distribution revealed that the greater the distance of the measurement point from the radiation source (tube), the smaller the dose received. In conclusion, the radiation dose received by accompanying caregivers is still below the Dose Limit Value (DLV) for caregivers, which is 5.000 µSv. However, to minimize stochastic effects, the implementation of additional protective measures, such as the use of lead aprons and selecting safer locations within the examination room, is highly recommended. These findings are expected to serve as a guide in enhancing the safety of accompanying caregivers of pediatric patients in conventional radiology units.
Abstract:This research examines the relevance of adopting the concept of active judges within adversarial common law traditions to Indonesia’s hybrid criminal procedure. The primary objective is to explore whether the active judge…
dge model can strengthen Indonesia’s criminal justice reform without undermining its civil law foundation. This study employs a normative juridical method with a comparative approach, analyzing doctrinal sources, statutory law, and scholarly debates from both civil law and common law perspectives. The findings suggest that while the adversarial system traditionally restricts judges to a passive role, the notion of an active judge has emerged to prevent procedural abuses and ensure substantive justice. For Indonesia, integrating aspects of the active judge model may contribute to enhancing transparency, protecting defendants’ rights, and harmonizing procedural justice with societal expectations. Nevertheless, challenges remain, particularly concerning judicial independence, consistency of application, and potential conflicts with established inquisitorial practices. This study concludes that the adoption of active judge principles must be carefully contextualized, reinforcing Indonesia’s hybrid system rather than replacing its legal traditions.
Abstract:The purpose of this study is to describe how local factors through a Buddhist approach influence the practice of religious moderation in the village of Rajabasa Lama, Labuhan Ratu District, East Lampung Regency, Lampung…
Province. The primary focus of this research is on the role of Buddhists in internalizing and implementing the four main pillars of religious moderation, namely commitment to nationalism, tolerance, anti-violence, and appreciation of local culture in the life of the village community. This study uses a qualitative approach with a phenomenological method. Data collection techniques involve participatory observation, in-depth interviews, and documentation studies. According to Colaizzi, the research procedure refers to the seven stages of phenomenology, while informants were selected using purposive sampling techniques. Data are analyzed through pattern matching, explanation making, and time series analysis. The research results show that Buddhist communities in the village of Rajabasa Lama have successfully implemented religious moderation by integrating the values of the Hasta Arya Marga teachings in Buddhism and the principles of multiculturalism in social life. National commitment, a sense of tolerance, anti-violence, and appreciation for their local culture are reflected in inclusive attitudes, active tolerance, and participation in interfaith activities without creating exclusive boundaries. This moderation process is formed through the practice of wisdom, morality, and concentration expressed in peaceful, ethical, and dialogical social discourse, thus strengthening a harmonious collective identity.
Abstract:This study examines the legal certainty of financing for Indonesia's Desa Merah Putih Cooperative (KDMP) initiative, analyzing the institutional tension between cooperative independence and state intervention. Rooted in…
the constitutional mandate for cooperatives as a cornerstone of the Indonesian economy, the KDMP program aims to establish 80,000 village-level cooperatives through state-facilitated credit lines and technical assistance. However, this top-down model raises concerns about undermining cooperative autonomy enshrined in Law No. 25/1992 and the principle of subsidiarity. Employing a normative juridical research design, this study draws on secondary data from legal literature and primary legal materials to systematically examine relevant norms and doctrines. Findings reveal a tenuous alignment between state financing mechanisms and cooperative autonomy, primarily due to the proposed reliance on state-owned bank credit lines rather than direct state budget grants, leading to legal ambiguity regarding accountability and oversight. The potential for mass loan defaults and the contentious use of Village Funds as collateral further complicate legal certainty and risk hidden liabilities. Comparative insights from India's Amul cooperative and the Philippines' barangay cooperatives illustrate successful models where government acts as a facilitator without impinging on cooperative self-governance or member control. This study advocates for a recalibrated regulatory approach featuring transparent oversight, proportional supervision, and participatory decision-making to reconcile developmental imperatives with cooperative principles, ultimately enhancing legal certainty and ensuring that state-supported cooperatives remain genuinely member-driven enterprises.
Abstract:This research was conducted in order to determine or to re-examine the performances of broiler chickens fed ration containing cinnamon bark powder (Cinnamomum burmannii). Eighty of CP 707 broiler chickens aged of 2 weeks…
ks were used and kept until 6 weeks old. Completely Randomized Design with 5 treatments and 4 replications each treatment was used in this study; the treatments used were, T0= 100% basal ration without cinnamon bark powder (CBP), T1= 99.5% basal ration + 0.5% CBP, T2= 99% basal ration + 1% CBP, T3= 98.5% basal ration + 1.5 % CBP, and T4= 98% basal ration + 2% CBP. The measurements taken were feed consumption, weight gain, feed conversion, and final body weight. The results of analysis of variance (ANOVA) and Duncan test showed that, giving cinnamon bark powder up to 2% in the ration had an effect on CP 707 broiler chickens aged 2-6 weeks; had a very significantly different effect (P<0.01) on body weight gained and so, on final body weight; and significantly different (P <0.05) on feed conversion, but not on feed consumption. In this study, the higher the level of CBP in the ration, the weight gained and final body weight decreased but feed conversion increased. Based on the results of the analysis and discussion, it can be concluded that giving cinnamon bark powder as a natural feed additive up to 2% in the feed did not improve the performance of CP 707 broiler chickens, because of weight gained and final body weight of the chickens decreased, while, feed conversion increased, which means that, economically it was not getting better.