Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:Drug management is a series of pharmaceutical service activities involving aspects of planning, requesting, receiving, storing, distributing, controlling, recording, and reporting drugs. Drug management in CHCs is an important…
ortant aspect because inefficiency will have a negative impact on health services. The purpose of this study was to evaluate drug management at the Camba Community Health Center UPTD so that it can be used as a reference material to improve the quality of drug management. This type of research is a non-experimental descriptive-observational study. The data used are data in the form of reports and documents on drug management at the community health center. The research instrument used an observation sheet with the references used being the Indonesian Minister of Health Regulation No. 74 of 2016 and the Indonesian Ministry of Health 2019 Technical Guidelines for Pharmaceutical Service Standards in CHCs. The results of the study indicate that drug management at the Camba Community Health Center UPTD is based on the Indonesian Minister of Health Regulation No. 74 of 2016 and the Indonesian Ministry of Health 2019 Technical Guidelines for Pharmaceutical Service Standards at CHCs in the planning aspect are included in the good category with a percentage value of 100%, the request aspect is 100% in the good category, the receipt aspect is 100% in the good category, the storage aspect is 87.5% in the good category, the distribution aspect is 66.7% in the sufficient category, the destruction and withdrawal aspect is 100% in the good category, the control aspect is 100% in the good category, the recording and reporting aspect is 100% in the good category. So it can be concluded that drug management at the Camba Community Health Center UPTD in 2024 has met the standards set by the Indonesian Ministry of Health.
Abstract:Abstract: Diabetes mellitus drugs using Decision Support System (DSS) techniques. The DSS method used is the Multi Objective Optimization method on the basis of ratio analysis (MOORA). The data used in the study are data…
sourced from BPS in ther Kisaran city area. Application development uses web and MySQL database as a help tool to test the ranking results on the selection of Diabetes mellitus drugs. The results of this study are expected to provide better results in helping to determine the best
Keywords : Decision Support System;MOORA Method;Diabetes mellitus;Drug Selection;Kisaran City
Abstrak: obat Diabetes melitus dengan menggunakan teknik Sistem Pendukung Keputusan (SPK). Metode SPK yang digunakan adalah metode Multi Objective Optimization On The Basis Of Ratio Analysis (MOORA). Data yang digunakan dalam penelitian adalah data bersumber dari BPS di wilayah kota Kisaran. Pengembangan aplikasi menggunakan web dan database MySQL sebagai perangkat bantuan untuk menguji hasil perangkingan pada pemilihan obat Diabetes melitus. Hasil dari penelitian ini diharapkan dapat memberikan hasil yang lebih baik dalam membantu menentukan obat diabetes terbaik
Kata Kunci : Sistem Pendukung Keputusan;Metode MOORA;Diabetes mellitus;Pemilihan Obat;Kota Kisaran
Abstract:Abstract: Drugs are a physical and mental health problem that has an impact on anxiety disorders, social behavior disorders, depression, lowers consciousness, disrupts quality of life and even causes death. The partner's…
problem is the lack of education for the young millennial generation in Teluk Kayu Putih Village regarding drug abuse. This service takes place in Teluk Kayu Putih Village, VII Koto District, Tebo Regency, Jambi Province. The aim of this outreach is to increase public awareness about the dangers of drug abuse for the young millennial generation. The material is presented through lecture and discussion methods with the help of power point slides and an LCD projector. The results of the outreach show that the generation of millennial youth in Teluk Kayu Putih Village is aware of the dangers and consequences of drug abuse.
Keywords: drugs; millennial young generation
Abstrak: Narkoba merupakan masalah kesehatan fisik dan mental yang berdampak terhadap gangguan kecemasan, gangguan prilaku sosial, depresi, menurunkan kesadaran, mengganggu kualitas hidup bahkan sampai menyebabkan kematian. Permasalah mitra yaitu kurangnya edukasi kepada generasi muda milenial di Desa Teluk Kayu Putih terhadap penyalahgunaan narkoba. Pengabdian ini bertempat di Desa Teluk Kayu Putih, Kecamatan VII Koto, Kabupaten Tebo, Provinsi Jambi. Tujuan penyuluhan ini adalah untuk meningkatkan kesadaran masyarakat tentang bahaya penyalahgunaan narkoba bagi generasi muda milenial. Materi disampaikan melalui metode ceramah dan diskusi dengan bantuan slide power point dan proyektor LCD. Hasil penyuluhan menunjukkan bahwa generasi pemuda milenial Desa Teluk Kayu Putih menyadari bahaya dan konsekuensi penyalahgunaan narkoba.
Kata kunci: penyalahgunaan narkoba; generasi muda milenial
Abstract:Indonesia International Institute for Life Sciences (i3L) and Lira Medika Hospital have developed a customized drug-drug interaction database, named as DDIBase. It has a comprehensive library for providing annotation-specific…
cific information toward the drug targets, mechanism, and interaction with other drugs. Hence, DDIBase is a new database with a brand-new user interface as well. In this regard, as DDIBase has currently reached beta stage of development, it is required to provide more comprehensive user feedback to improve its features. Thus, a workshop has been devised to explain the user guidelines, while a training has been conducted to provide system demo and user hand-on. The workshop and training attendees are faculty members of the i3L and Lira Medika Hospital Staffs. A survey has been developed to cater the user satisfaction toward the DDIBase. In this end, the survey has elicited good user satisfaction toward the developed user interface.
Abstract:Abstract: The emergence of some diseases that often attack school-age children, it turns out generally related to Clean and Healthy Life Behavior (PHBS). Other schools function as a place of learning and can also be a threat…
reat of disease transmission if not managed properly. More than that, school age for children is also a vulnerable period of various diseases. Therefore, the planting of PHBS values in schools is an absolute necessity and can be done through an approach with the PMR (Youth Red Cross) which is assisted by the local PMI (Indonesian Red Cross. In the hope that PMR members can carry out the Promotion Efforts to realize Clean and Healthy Life Behavior in the school environment to realize a Healthy School. The specific target of this activity will involve 30 members of the Intermediate PMR in the PMI Area of Magelang City. This activity includes the provision of material related to the technique of washing hands properly and properly and maintaining personal hygiene, the dangers of cigarettes and drugs, HIV AIDS, and the use of healthy latrines. Implementation with simulations for the application of Clean and Healthy Behavior through campaigns and demonstrations.
Keywords: PHBS, PMR, school
Abstrak: Munculnya sebagian penyakit yang sering menyerang anak usia sekolah, ternyata umumnya berkaitan dengan Perilaku Hidup Bersih dan Sehat (PHBS). Sekolah selain berfungsi sebagai tempat pembelajaran juga dapat menjadi ancaman penularan penyakit jika tidak dikelola dengan baik. Lebih dari itu, usia sekolah bagi anak juga merupakan masa rawan terserang berbagai penyakit. Oleh karena itu, penanaman nilai-nilai PHBS disekolah merupakan kebutuhan mutlak dan dapat dilakukan melalui pendekatan dengan PMR (Palang Merah Remaja) yang merupakan binaan dari PMI (Palang Merah Indonesia) setempat..Target khusus kegiatan ini akan melibatkan 30 anggota PMR Madya di wilayah Binaan PMI Kota Magelang. Kegiatan ini meliputi pemberian materi terkait teknik mencuci tangan dengan baik dan benar serta menjaga kebersihan diri, Bahaya Rokok dan Napza, HIV AIDS, serta Penggunaan Jamban Sehat. Implementasi dengan adanya simulasi untuk penerapan Perilaku Hidup Bersih dan Sehat melalui bentuk kampanye dan demonstrasi. Tujuan kegiatan pengabdian ini adalah meningkatkan pemahaman dan perilaku sasaran dalam memahami serta menerapkan perilaku hidup bersih dan sehat dan dapat mengaplikasikan dalam upaya menjaga kesehatan lingkungan sekolah dengan menghindari perilaku-perilaku yang beresiko menimbulkan penyakit.
Kata kunci: PHBS, PMR, sekolah
Abstract:Abstract: Managing fast-moving drug inventory requires accurate supplier selection to ensure product availability and minimize the risk of overstock and out-of-stock conditions. At Annisa Pharmacy, the supplier selection…
process has traditionally relied on experience and subjective judgment, which may lead to less optimal decisions. This study aims to design and implement a Decision Support System (DSS) for selecting fast-moving drug suppliers using the Weighted Product (WP) method. The WP method is applied because it is capable of processing multiple criteria simultaneously through structured weighting, including demand frequency, delivery lead time, remaining shelf life, purchase price, and profit margin. The system is developed as a web-based application using PHP and MySQL. The results show that the implementation of the Weighted Product method successfully produces preference values and accurate supplier rankings, enabling the system to correctly determine the most optimal fast-moving drug supplier based on the defined criteria. Therefore, the developed system can assist the owner of Annisa Pharmacy in making more precise, objective, and structured inventory procurement decisions.
Keywords: decision support system; drug inventory; supplier selection; weighted product.
Abstrak: Pengelolaan stok obat fast moving di Toko Obat Annisa memerlukan ketepatan dalam menentukan supplier agar ketersediaan obat tetap terjaga dan risiko overstock maupun out of stock dapat diminimalkan. Selama ini, proses pemilihan supplier masih dilakukan secara konvensional berdasarkan pengalaman, sehingga berpotensi menghasilkan keputusan yang kurang optimal. Penelitian ini bertujuan untuk merancang dan mengimplementasikan Sistem Pendukung Keputusan (SPK) pemilihan supplier obat fast moving menggunakan metode Weighted Product (WP). Metode WP digunakan karena mampu mengolah beberapa kriteria secara simultan melalui pembobotan yang terstruktur, meliputi frekuensi permintaan, lead time, sisa masa kedaluwarsa, harga beli, dan margin keuntungan. Sistem dikembangkan berbasis web menggunakan bahasa pemrograman PHP dan basis data MySQL. Hasil penelitian menunjukkan bahwa penerapan metode Weighted Product mampu menghasilkan nilai preferensi dan perankingan supplier secara objektif, sehingga sistem berhasil menentukan supplier obat fast moving yang paling optimal sesuai dengan kriteria yang telah ditetapkan. Dengan demikian, sistem yang dibangun dapat membantu pemilik Toko Obat Annisa dalam mengambil keputusan pengadaan stok obat secara lebih tepat, objektif, dan terstruktur.
Kata kunci: sistem pendukung keputusan; toko obat; pemilihan pemasok; weighted product
Abstract:Abstract: Inventory management of consumable medical devices and drugs plays a crucial role in maintaining the continuity of healthcare operations. However, Jelita Dental Care still faces challenges in recording and controlling…
rolling stock due to manual procedures, which can lead to data inaccuracy, procurement delays, and the risk of stockouts. To address these issues, this study aims to develop a web-based Electronic Supply Chain Management (E-SCM) system that integrates stock monitoring and procurement processes. The Reorder Point (ROP) method is applied to determine the optimal reorder point based on average demand, lead time, and safety stock. This system was built using the PHP programming language and MySQL database. The results show that the JelitaMed system is able to improve the effectiveness and accuracy of inventory management, simplify the structured procurement submission process between the admin, owner, and supplier, and support decision-making in maintaining the availability of consumable medical devices and drugs. Thus, the implementation of E-SCM combined with the ROP method is a practical solution to improve inventory control in small-scale health clinics.
Keywords: e-scm; inventory; information system; medical supplies; reorder point.
Abstrak: Pengelolaan persediaan alat dan obat medis habis pakai memiliki peran penting dalam menjaga keberlangsungan operasional layanan kesehatan. Namun, Jelita Dental Care masih menghadapi kendala dalam pencatatan dan pengendalian stok akibat prosedur manual, yang dapat menyebabkan ketidaktepatan data, keterlambatan pengadaan, serta risiko kekurangan persediaan. Untuk mengatasi permasalahan tersebut, penelitian ini bertujuan mengembangkan sistem Electronic Supply Chain Management (E-SCM) berbasis web yang mengintegrasikan pemantauan stok dan proses pengadaan. Metode Reorder Point (ROP) diterapkan untuk menentukan waktu pemesanan ulang yang optimal berdasarkan permintaan rata-rata, lead time, dan safety stock. Sistem ini dibangun menggunakan bahasa pemrograman PHP dan database MySQL. Hasil penelitian menunjukkan bahwa sistem JelitaMed mampu meningkatkan efektivitas dan akurasi pengelolaan persediaan, mempermudah proses pengajuan pengadaan secara terstruktur antara admin, owner, dan supplier, serta mendukung pengambilan keputusan dalam menjaga ketersediaan alat dan obat medis habis pakai. Dengan demikian, penerapan E-SCM yang dikombinasikan dengan metode ROP menjadi solusi praktis untuk meningkatkan pengendalian persediaan pada klinik kesehatan skala kecil.
Kata kunci: alat medis; e-scm; persediaan; reorder point; sistem informasi
Abstract:Abstract: The management of veterinary drug stocks at the Veterinary Clinic Technical Implementation Unit (UPTD) of the North Sumatra Province Plantation and Livestock Service faces obstacles in the form of discrepancies…
between supply and demand, resulting in excess stock and budget waste. Uncertain demand for drugs is a factor that complicates decision-making in stock provision. This study aims to optimize drug stock management using the Mamdani fuzzy logic method, which is capable of handling data uncertainty and modeling information linguistically. Three input variables are used, namely initial stock, demand, and number of visits, with the output being the final stock. The process involves fuzzification, inference based on IF–THEN rules, and defuzzification using the centroid method. The results show that the developed system has a good accuracy level with a MAPE value of 17.52%, which means that this model is effective in providing optimal and efficient drug stock recommendations in a veterinary clinic environment.
Keywords: fuzzy mamdani; optimization; animal drug stock.
Abstract:Abstract: Technological developments open up opportunities to improve health services, especially in the diagnosis of female reproductive health problems. This research discusses the development of an expert system at Utama…
ama General Hospital in Kisaran to assist in the early diagnosis of female reproductive diseases. The problems that occur in this article are the absence of knowledge about dangerous diseases, lack of awareness of reproductive health diseases, remote and hard-to-reach locations of health facilities, high costs for consultations and drugs, and long time to get diagnostic results. The method used in solving these problems is Case Based Reasoning (CBR), where the system uses the experience of previous cases to handle new cases. The process involves collecting patient data, building a knowledge base, and developing an expert system using the CBR approach. Test results show the system is able to provide accurate diagnosis based on the symptoms inputted by the user. Solutions for each disease are displayed, providing useful information for further treatment. In conclusion, the development of this expert system is expected to improve the accessibility and quality of women's reproductive health services by providing fast and appropriate solutions.
Keywords: case based reasoning (CBR) method; expert system; main public hospital kisaran; women's reproduction.
Abstrak: Perkembangan teknologi membuka peluang untuk meningkatkan layanan kesehatan, terutama dalam diagnosis masalah kesehatan reproduksi wanita. Artikel ini membahas pengembangan sistem pakar di Rumah Sakit Umum Utama Kisaran untuk membantu diagnosis dini penyakit reproduksi wanita. Masalah yang terjadi pada penelitian ini yaitu Tidak adanya pengetahuan tentang penyakit berbahaya, kurangnya kesadaran akan penyakit kesehatan reproduksi, lokasi fasilitas kesehatan yang terpencil dan sulit dijangkau, biaya tinggi untuk konsultasi dan obat, serta waktu yang lama untuk mendapatkan hasil diagnosa. Adapun metode yang digunakan dalam menyelesaikan masalah tersebut adalah Case Based Reasoning (CBR), di mana sistem menggunakan pengalaman kasus sebelumnya untuk menangani kasus baru. Proses melibatkan pengumpulan data pasien, pembentukan basis pengetahuan, dan pengembangan sistem pakar menggunakan pendekatan CBR. Hasil pengujian menunjukkan sistem mampu memberikan diagnosis akurat berdasarkan gejala yang diinputkan oleh pengguna. Solusi untuk setiap penyakit ditampilkan, memberikan informasi yang berguna untuk penanganan lebih lanjut. Kesimpulannya, pengembangan sistem pakar ini diharapkan meningkatkan aksesibilitas dan kualitas layanan kesehatan reproduksi wanita dengan memberikan solusi yang cepat dan tepat.
Kata kunci: metode case based reasoning (CBR); reproduksi wanita; rumah sakit umum utama kisaran; sistem pakar.