Abstract:Background: Cardiovascular disease (CVD) continues to be the predominant cause of global mortality. Polypill techniques that integrate various cardiovascular drugs into a single formulation have emerged as a potential method…
thod for primary prevention, especially in intermediate-risk populations.
Objective: To systematically review and synthesize evidence regarding the efficacy and safety of polypill formulations (comprising antihypertensive medications, statins, with or without aspirin) in comparison to standard care or placebo for the primary prevention of major adverse cardiovascular events (MACE) in intermediate-risk populations.
Methods: We conducted systematic review and meta-analysis in accordance with PRISMA 2020 standards (Systematic Review Registration: PROSPERO CRD420251184718). Various databases (PubMed, Cochrane Library, ScienceDirect, Scopus) were examined for original research published from January 2015 to October 2024. Studies were eligible if they assessed polypill therapies in individuals aged 30 to 70 years with intermediate cardiovascular risk (10-20% 10-year risk), reported composite major adverse cardiovascular events (MACE) outcomes, and included a minimum follow-up of 6 months. Two independent reviewers conducted screening, data extraction, and risk of bias evaluation utilizing the Cochrane RoB 2.0 tool.
Results: Of the 161 records discovered, 4 randomized controlled studies (HOPE-3, TIPS-3, PolyIran, PolyPars) with 31,501 people fulfilled the inclusion criteria. Polypill therapies showed a substantial decrease in composite MACE relative to control groups (pooled HR 0.67 (95% CI 0.60-0.75, p<0.001). Individual trial hazard ratios varied from 0.50 (PolyPars) to 0.66 (PolyIran) and 0.79 (TIPS-3) with moderate heterogeneity (I²=35.2%, p=0.20). Polypills were generally well- tolerated, with a safety profile consistent with the individual components. Medication adherence was enhanced with the polypill in comparison to multiple-pill regimens.
Conclusions: Polypill techniques markedly reduce major adverse cardiovascular events (MACE) in intermediate-risk patients for primary cardiovascular prevention, achieving around a 33% relative risk reduction. The fixed-dose combination strategy provides benefits in compliance and ease of use. These findings hold significant implications for healthcare systems in low-to-
middle-income nations, such as Indonesia, where the burden of cardiovascular disease is substantial and access to long-term cardiovascular drugs is frequently hindered by cost and complexity.
Abstract:Penelitian ini bertujuan untuk menganalisis pengaruh manajemen organisasi digital terhadap kinerja pelayanan publik pada pemerintah daerah di Indonesia. Transformasi digital dalam sektor publik menjadi salah satu strategi…
i pemerintah untuk meningkatkan efektivitas organisasi, efisiensi birokrasi, transparansi, akuntabilitas, dan kualitas pelayanan kepada masyarakat. Namun demikian, implementasi manajemen organisasi digital masih menghadapi berbagai tantangan, antara lain keterbatasan kompetensi digital aparatur sipil negara (ASN), kesiapan infrastruktur teknologi informasi, serta budaya organisasi yang belum sepenuhnya adaptif terhadap perubahan digital. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Populasi penelitian adalah aparatur sipil negara pada beberapa organisasi perangkat daerah, sedangkan sampel ditentukan menggunakan teknik purposive sampling sebanyak 120 responden. Pengumpulan data dilakukan melalui penyebaran kuesioner menggunakan skala Likert lima tingkat. Analisis data dilakukan secara deskriptif kuantitatif melalui perhitungan nilai rata-rata setiap indikator untuk menggambarkan tingkat penerapan manajemen organisasi digital dan kinerja pelayanan publik. Hasil penelitian menunjukkan bahwa penerapan manajemen organisasi digital berada pada kategori baik dengan nilai rata-rata 4,12, sedangkan kinerja pelayanan publik memperoleh nilai rata-rata 4,17 yang juga berada pada kategori baik. Indikator kepemimpinan digital memperoleh nilai tertinggi, sedangkan kompetensi digital ASN menjadi indikator dengan nilai terendah. Temuan penelitian menunjukkan bahwa semakin baik penerapan manajemen organisasi digital, semakin tinggi pula kualitas kinerja pelayanan publik. Oleh karena itu, pemerintah daerah perlu memperkuat kompetensi digital ASN, meningkatkan infrastruktur teknologi informasi, mengembangkan inovasi pelayanan berbasis digital, serta membangun budaya organisasi yang adaptif guna mewujudkan pelayanan publik yang efektif, efisien, transparan, dan berorientasi pada kepuasan masyarakat.
Abstract:Penelitian ini bertujuan untuk mengkaji dan mensintesis peran Human Resource Development (HRD) atau Pengembangan Sumber Daya Manusia sebagai agen kunci dalam proses pengembangan organisasi. Metode yang digunakan adalah studi…
tudi literatur sistematis, di mana data dikumpulkan dari berbagai jurnal ilmiah, buku, dan laporan penelitian yang relevan. Analisis data dilakukan dengan pendekatan naratif-interpretatif untuk mengidentifikasi tema-tema utama dan tren yang muncul. Hasil kajian menunjukkan bahwa HRD memiliki tiga peran utama dalam pengembangan organisasi, yaitu (1) peran strategis dalam menyelaraskan tujuan individu dengan visi organisasi, (2) peran operasional melalui program-program pelatihan dan pengembangan, serta (3) peran transformasional dalam memfasilitasi perubahan budaya dan struktur organisasi. Temuan ini menegaskan bahwa HRD bukan sekadar fungsi administratif, melainkan mitra strategis yang esensial dalam memastikan keberlanjutan dan pertumbuhan organisasi di tengah dinamika lingkungan bisnis.
Abstract:Public organizational development is a crucial aspect in realizing effective and efficient service delivery. Employees’ attitudes toward organizational change play a key role in determining the success of this process. This…
This article employs a literature review method to analyze the influence of attitudes in public organizational development. The review findings indicate that positive attitudes, such as openness to change and work commitment, significantly support bureaucratic reform. A competency- and performance-based approach serves as the foundation for building an adaptive work culture. Recommendations include strengthening attitude development programs, effective communication, and inspiring leadership to support organizational change in the public sector.
Keywords: attitude, public organizational development, bureaucratic reform, competency, performance
Abstract:Setiap organisasi terus bersaing dan berkompetisi serta berproses bersama semua sumberdaya yang ada pada dirinya untuk mengembangkan dan membesarkan organisasi tersebut. Salah satu strategi pengembangan organisasi yang dilakukan…
ilakukan adalah dengan berbasis pada kompetensi kinerja dengan harapan dapat tetap bersaing dan mengembangkan organisasinya mencapai tujuan organisasi tersebut. Dengan demikian tujuan dari penelitian ini adalah untuk mengetahui tentang bagaimana desain inovasi organisasi dalam meningkatkan pelayanan publik. Metode yang digunakan dalam penulisan artikel ini adalah literature review atau tinjauan pustaka. Hasil dari penelitian ini adalah dalam prakterknya pengembangan organisasi kompetensi dilakukan dalam rangka menanta dan memperbaiki kembal organsiasi untuk berkerja sesuai dengan harapan demi pencapaian tujuan organisasi.
Kata Kunci: Inovasi, Organisasi, Pelayanan Publik
Abstract:Every organisation must be able to compete and process with all the resources available to it to develop and grow the organisation. One of the organisational development strategies carried out is based on performance competencies…
competencies in the hope of remaining competitive and developing the organisation to achieve the organisation's goals. Thus the purpose of this research is to find out about how the design of performance competencies in an effort to develop the organisation as a whole. The method used in writing this article is literature review or literature review. The result of this research is that in practice organisational development competencies are carried out in order to monitor and improve the organisation to work in accordance with expectations for the achievement of organisational goals.
Keywords: Development, Organisation, Competence
Abstract:Sexual violence can occur in any environment, including the family. Most victims of sexual violence are women. One narrative depicting violence in a family context is the story of Tamar and Amnon in 2 Samuel 13:1-39, which…
ch is part of King David’s family history. The family, which should be a place of refuge, instead becomes an unsafe place. The patriarchal system that gives power to men and places women in a subordinate position is one of the causes. The text of 2 Samuel 13:1-39 is implied in the modern context because the problem of sexual violence in private spaces such as the home is also experienced by women today. A feminist approach is used to draw out women’s values and analyze the structure of the Davidic Kingdom family, identifying the causes and impacts, and how Tamar, as a woman, faced and overcame the moral crisis and sexual violence she experienced. This study uses a qualitative descriptive method with a hermeneutic approach, focusing on literature review to discuss related topics. The author found that Tamar, who experienced sexual violence in the family environment, did not receive justice. The cause of violence is the patriarchal system. Power struggles and invalid laws. Tamar did not remain silent but sought justice for herself by communicating her experiences to the public through religious and social symbolism. Learning from Tamar teaches modern women how to speak out about the injustices they experience.
Abstract:Abstract: The pandemic has caused the economy to decline drastically, even many residents have lost their sources of livelihoods. The government directly disbursed funds in the form of Direct Cash Assistance. The problem…
that arose was the suspicion of injustice for the villagers who received BLT. There is a need for a transparent system to inform the criteria for BLT recipients. The more criteria for poor and vulnerable families that were met, the priority for BLT village fund recipients. BLT priority assessment based on the aspect of the criteria that apply by law is implemented using PhpMyadmin. The development of a web-based information system made it easier to inform villagers of the names of BLT priority recipients based on the reasons that had been collected and then ranked. The resulting system helps employees of the Pagar Jati Village office to inform BLT recipients in a technological system built with the water fall method including data collection, problem analysis, design, testing and system evaluation.
Keywords: devotion; information systems; priority setting; web based
Abstrak: Pendemi mengakibatkan perekonomian menurun drastis, bahkan banyak warga yang kehilangan sumber mata pencaharian. Pemerintah secara langsung mengucurkan dana dalam bentuk Bantuan Langsung Tunai (BLT). Permasalahan yang timbul yaitu kecurigaan adanya ketidakadilan bagi warga desa penerima BLT. Perlu adanya sistem yang transparan menginformasikan kriteria penerima BLT. Semakin banyak kriteria keluarga miskin dan rentan yang dipenuhi, menjadi prioritas penerima BLT dana desa. Penilaian prioritas BLT berdasarkan aspek kriteria yang berlaku secara undang-undang diimplementasikan menggunakan PhpMyadmin. Pengembangan sistem informasi berbasis web mempermudah menginformasikan pada warga desa nama-nama penerima prioritas BLT berdasarkan alasan-alasan yang sudah dikumpulkan lalu diranking. Sistem yang dihasilkan membantu pegawai kantor Desa Pagar Jati menginformasikan penerima BLT secara sistem teknologi yang dibangun dengan metode water fall meliputi pengumpulan data, analisa permasalahan, perancangan, pengujian dan evaluasi sistem.
Kata kunci:berbasis web; penentuan prioritas; pengabdian; sistem informasi
Abstract:Abstract: The city of Surakarta is one of the cities that is busy with local and foreign tourists because there are various kinds of interesting cultural tourism. The large number of hotels with many services and facilities…
ies makes tourists confused in choosing a hotel, so prospective hotel guests need a long time to choose the best hotel according to their desired criteria. The aim of this research is to create a tool for prospective hotel guests in making decisions on hotel selection recommendations using the TOPSIS and SAW methods. This research uses 8 hotel data points in Laweyan District, Surakarta, and hotel data obtained from the Tourism Office. The results of the McCall Test with 5 indicators, namely accuracy, reliability, efficiency, integrity, and usability, average 86%, so this system is categorized as very good.
Keywords: hotel selection; TOPSIS; SAW; decision supporter system
Abstrak: Kota Surakarta menjadi salah satu kota yang ramai dikunjungi wisatawan lokal maupun mancanegara karena terdapat berbagai macam wisata budaya yang menarik. Banyaknya hotel dengan pelayanan dan fasilitas yang banyak membuat wisatawan kebingungan dalam memilih hotel, sehingga calon tamu hotel memerlukan waktu yang lama untuk memilih hotel terbaik sesuai kriteria yang diinginkan. Tujuan dari penelitian ini adalah membuat suatu alat bantu bagi calon tamu hotel dalam pengambilan keputusan rekomendasi pemilihan hotel menggunakan metode TOPSIS dan SAW. Penelitian ini menggunakan 10 titik data hotel yang ada di Kecamatan Laweyan Surakarta dan data hotel yang diperoleh dari Dinas Pariwisata. Hasil Uji McCall dengan 5 indikator yaitu akurasi, reliabilitas, efisiensi, integritas, dan kegunaan rata-rata 86%, maka sistem ini dikategorikan sangat baik.
Kata kunci: pemilihan hotel; TOPSIS; SAW; sistem penunjang keputusan
Abstract:Abstract: MSMEs are an essential sector in regional economic growth. Up to now, Papua Province has been trying to improve the economy. Still, it seems not optimal, as seen from the Human Development Index and the Percentage…
age of the Poor Population, where Papua occupies the last rank. One of the causes found here is the processing of MSMEs that have not been optimal. MSME data collection services are still done manually with Microsoft Excel. This impacts making strategic policies for SMEs that are not optimal because their data are not updated. This study aims to develop a web-based MSME data collection application to facilitate the SME field admin and MSME actors for the data collection process. The method used in making this application is the waterfall method, where the development of this application is done sequentially. The final result of this study resulted in an easy application for collecting data on SMEs and updating data. In addition, it is also in the form of data collection reports for MSMEs and mapping of beneficiaries each year.
Keywords: Laravel Framework; UMKM Data Collection; Waterfall
Abstrak: UMKM merupakan sektor yang penting dalam pertumbuhan perekonomian daerah. Selama ini Provinsi Papua berusaha meningkatkan perekonomian, namun terkesan belum optimal, dapat dilihat dari Indeks pembangunan Manusia serta Persentasi penduduk Miskin, dimana Papua menempati Posisi terakhir di Indonesia. Salah satu penyebab yang di temukan disini adalah pengolahan UMKM yang belum optimal. Pelayanan pendataan UMKM masih dilakukan secara manual dengan Microsoft Excel. Hal tersebut berdampak dalam pengambilan kebijakan strategis UMKM yang tidak optimal, karena data yang dimiliki tidak up to date. Penelitian ini bertujuan tunk mengembangkan aplikasi pendataan UMKM berbasis web untuk mempermudah admin bidang UKM maupun pelaku UMKM untuk proses pendataan. Metode yang digunakan dalam pembuatan aplikasi ini adalah metode waterfall, dimana pengembangan aplikasi ini lakukan secara berurutan. Hasil akhir penelitian ini menghasilkan aplikasi yang mudah untuk untuk pendataan UMKM serta updating data. Selain itu juga berupa laporan pendataan UMKM dan juga pemetaan penerima bantuan setiap tahunnya.
Kata kunci: Framework Laravel; Pendataan UMKM; Waterfall,