Abstract:Antimicrobial resistance has driven the urgent need to develop new antibacterial candidates with favorable efficacy, pharmacokinetic properties, and safety profiles. Aaptamine derivatives, secondary metabolites isolated…
from marine sponges of the genus Aaptos, have demonstrated potential as drug candidates; however, studies evaluating their drug-likeness, Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and toxicity profiles remain limited. This study aimed to prioritize aaptamine, demethyl(oxy)aaptamine, and isoaaptamine as potential antibacterial candidates through SwissADME and ProTox-II analyses using an in silico approach. The results demonstrated that all three compounds satisfied the Lipinski's Rule of Five criteria for drug-likeness, exhibited high gastrointestinal absorption, and achieved a bioavailability score of 0.55. All compounds were predicted to belong to toxicity class 4, with predicted LD₅₀ values of 1300 mg/kg for aaptamine, 500 mg/kg for demethyl(oxy)aaptamine, and 1350 mg/kg for isoaaptamine, while none showed hepatotoxic or cytotoxic properties. The integrated analysis indicated that isoaaptamine exhibited the most balanced drug-likeness, ADME profile, and safety characteristics, making it the highest-priority antibacterial candidate. This study concludes that the integration of SwissADME and ProTox-II provides an effective preliminary approach for screening marine natural product-derived drug candidates. The novelty of this study lies in the integrated application of drug-likeness, ADME, and toxicity analyses to systematically prioritize three aaptamine derivatives, thereby providing a more comprehensive lead compound selection strategy for antibacterial drug discovery.
Abstract:Bankruptcy risk is a critical issue for publicly listed companies as it may threaten business sustainability and undermine investor confidence. This study aims to examine the effects of asset growth, revenue growth, market…
et valuation, property, plant and equipment (PPE), goodwill, and research and development expenditure on bankruptcy risk, proxied by the Altman Z-score, among publicly listed companies in ASEAN countries. The study employs a quantitative approach using secondary data obtained from 1,354 non-financial firms listed in Indonesia, Malaysia, Thailand, Singapore, and the Philippines over the 2015–2023 period, yielding a total of 7,726 firm-year observations. Data were analyzed using a fixed-effects panel regression model. The findings reveal that asset growth and goodwill exert a positive and significant effect on the Altman Z-score, whereas research and development expenditure has a negative and significant effect. Revenue growth demonstrates a marginally positive influence, while market valuation and PPE do not exhibit a significant effect on bankruptcy risk. These results suggest that corporate financial stability is determined not only by financial factors but also by the quality of strategic resources and firms’ adaptive capabilities. The novelty of this study lies in the integration of the Resource-Based View and Dynamic Capabilities Theory perspectives into a bankruptcy prediction framework for publicly listed companies across ASEAN countries.
Abstract:Chronic Obstructive Pulmonary Disease (COPD) is a progressive chronic respiratory disease that has become a global health concern due to its high morbidity and mortality rates and its impact on patients’ quality of life.…
e. In acute exacerbation conditions, impaired oxygenation becomes a major problem that may be influenced by various factors, including hemoglobin levels as the primary component of oxygen transport in the blood. However, the relationship between hemoglobin levels and oxygen saturation in patients with acute exacerbation COPD remains inconsistent, particularly in populations exposed to high environmental risk factors. This study aimed to determine the relationship between hemoglobin levels and oxygen saturation in patients with acute exacerbation COPD hospitalized at RSUD dr. Suhatman MARS Dumai, Kota Dumai. This research employed an analytic observational design with a cross-sectional approach involving 73 patients selected through total sampling based on medical record data. Bivariate analysis using the Spearman correlation test showed no significant relationship between hemoglobin levels and oxygen saturation (r = 0.098; p = 0.412), indicating a very weak and statistically insignificant correlation. The study concluded that hemoglobin levels do not directly influence the oxygenation status of patients with acute exacerbation COPD, where impaired oxygenation is more strongly affected by respiratory factors such as ventilation-perfusion imbalance and structural lung damage. The novelty of this study lies in its empirical evidence demonstrating the limited role of hemoglobin as a predictor of oxygenation in patients with acute exacerbation COPD within a population with specific environmental characteristics, thereby providing a basis for developing more comprehensive clinical approaches in monitoring and managing COPD patients.
Abstract:Stunting remains a crucial public health issue in Indonesia as it has multidimensional impacts on physical growth, cognitive development, productivity, and the long-term quality of human resources. This study aims to analyze…
lyze the potential application of predictive Artificial Intelligence (AI)-based Wearable Health Technology in preventing child stunting, with an emphasis on the integration of technology into the health system, socio-cultural interrelations, and ethical dimensions that need to be anticipated. The research employed a qualitative approach through a systematic literature review, analysis of national health policies, and examination of reports on the implementation of digital health technologies related to child health. The results indicate that wearable devices are effective in recording health indicators in real-time, while predictive AI algorithms enable early detection of stunting risks, allowing interventions to be carried out quickly, accurately, and in a personalized manner. However, the success of implementation is highly dependent on the support of the digital health ecosystem, including adaptive regulations, infrastructure readiness, digital literacy among communities, as well as multi-stakeholder collaboration involving the government, medical professionals, the technology industry, and families. This study affirms that the integration of Wearable Health Technology and predictive AI is not merely an additional tool in medical services, but rather a representation of a health system transformation towards a more preventive, predictive, precise, and participatory paradigm. Thus, the utilization of evidence-based digital innovations has the potential to strengthen the effectiveness of stunting prevention programs in Indonesia while accelerating the achievement of national health development targets within the context of technological disruption and global dynamics.
Abstract:The development of science is very rapid. Competition is increasingly fierce and people are required to have high intellectual abilities in facing the challenges of the global world. In fact, the progress of a nation will…
l be recognized by the world, one factor is how the majority of people in a country master, develop and utilize science and technology. The purpose of writing this literature review is none other than to explain in detail the development of individuals in facing developments in science, which has so far become a topic of discussion in the world of education. This research uses a descriptive qualitative method, namely research in the form of a literature study which aims to analyze, evaluate, identify, observe, find and determine relevant research topics. The results of data analysis conclude that science and technology are human achievements that must be utilized in understanding and practicing something. In line with this principle, science is actually a process experienced by individuals in their development. The poorer the knowledge, the narrower the insight in understanding something, the narrower a person's thinking about a science. In conclusion, development is a skill in the structure and function of the body or an increase in more complex abilities in a regular and predictable pattern as a result of experience and the maturation process. Development is also very closely related to social, motor, intellectual and emotional abilities. So it becomes very necessary how a learning design is formed to provide freedom to be creative on an ongoing basis in order to optimize and develop students work.
Abstract:Abstract: This study is motivated by the underutilization of transaction data at Toko F3I Kisaran in supporting decision-making related to inventory and pricing strategies. Currently, decisions are made conventionally based…
sed on experience, which may lead to overstock or stockout conditions. This research aims to develop a sales prediction model by applying Data Mining techniques using the Multiple Linear Regression method to analyze the influence of stock and price variables on sales. The research methodology includes historical data collection, regression analysis, web-based system design using PHP and MySQL, and system testing through the Black Box method. The results indicate that the developed model is capable of generating measurable and systematic sales estimations based on stock and price variables. The implementation of this system can assist store management in planning inventory levels and pricing strategies more efficiently, thereby improving operational effectiveness and business competitiveness.
Keywords: data mining; multiple linear regression; PHP; sales prediction; web-based system
Abstrak: Penelitian ini dilatarbelakangi oleh belum optimalnya pemanfaatan data transaksi penjualan pada Toko F3I Kisaran dalam mendukung pengambilan keputusan terkait persediaan dan penetapan harga. Selama ini, keputusan masih dilakukan secara konvensional berdasarkan pengalaman, sehingga berpotensi menimbulkan overstock maupun stockout. Penelitian ini bertujuan untuk membangun model prediksi penjualan dengan menerapkan teknik Data Mining menggunakan metode Regresi Linier Berganda guna menganalisis pengaruh variabel stok dan harga terhadap penjualan. Metodologi penelitian meliputi pengumpulan data historis, analisis perhitungan regresi, perancangan sistem berbasis web menggunakan PHP dan MySQL, serta pengujian sistem dengan metode Black Box. Hasil penelitian menunjukkan bahwa model yang dibangun mampu menghasilkan estimasi penjualan berdasarkan variabel stok dan harga secara lebih terukur dan sistematis. Implementasi sistem ini dapat membantu manajemen toko dalam merencanakan jumlah persediaan dan strategi harga secara lebih efisien, sehingga meningkatkan efektivitas pengelolaan bisnis dan daya saing perusahaan.
Kata kunci: data mining; prediksi penjualan; regresi linier berganda; sistem berbasis web; PHP
Abstract:Abstract: This study aims to classify the nutritional status of toddlers based on anthropometric data using the K-Nearest Neighbor (KNN) algorithm. Data were obtained from 20 Integrated Health Posts (Posyandu) in Rumbai…
Timur District, including Lembah Sari Village and Limbungan Village with a total of 1,000 toddler data. After cleaning and preprocessing, 782 data were obtained ready for use. The preprocessing stages include data cleaning and transformation, outlier removal, minority class handling, and data normalization. Next, data balancing was carried out using the Synthetic Minority Oversampling Technique (SMOTE) to address class imbalance. The data was divided into 80% training data and 20% test data, then the K parameter was tested from 1 to 15 using 5-fold cross-validation. The results showed that the value of K = 1 provided the best performance with a macro recall of 0.8827 and an accuracy of 86.26%. These results indicate that the combination of the KNN algorithm with the SMOTE method and Min-Max normalization is effective in improving classification performance on imbalanced data and producing accurate and balanced predictions of toddler nutritional status between classes.
Keywords: k-nearest neighbor; toddler nutritional status; SMOTE; min-max scaling; classification; anthropometric data
Abstrak: Penelitian ini bertujuan untuk mengklasifikasikan status gizi balita berdasarkan data antropometri menggunakan algoritma K-Nearest Neighbor (KNN). Data diperoleh dari 20 Posyandu di Kecamatan Rumbai Timur, meliputi Kelurahan Lembah Sari dan Kelurahan Limbungan dengan total 1.000 data balita. Setelah melalui proses cleaning dan preprocessing, diperoleh 782 data yang siap digunakan. Tahapan pra-pemrosesan meliputi pembersihan dan transformasi data, penghapusan outlier, penanganan kelas minoritas, serta normalisasi data. Selanjutnya dilakukan penyeimbangan data menggunakan Synthetic Minority Oversampling Technique (SMOTE) untuk mengatasi ketidakseimbangan kelas. Data dibagi menjadi 80% data latih dan 20% data uji, kemudian dilakukan pengujian parameter K dari 1 hingga 15 menggunakan 5-fold cross-validation. Hasil penelitian menunjukkan bahwa nilai K = 1 memberikan performa terbaik dengan recall macro sebesar 0,8827 dan akurasi 86,26%. Hasil ini menunjukkan bahwa kombinasi algoritma KNN dengan metode SMOTE dan normalisasi Min-Max efektif dalam meningkatkan kinerja klasifikasi pada data tidak seimbang serta menghasilkan prediksi status gizi balita yang akurat dan seimbang antar kelas.
Kata kunci: k-nearest neighbor; status gizi balita; SMOTE; min-max scaling; klasifikasi; data antropometri
Abstract:Abstract: Motorcycle sales are one of the key indicators of growth in Indonesia’s automotive industry. CV. Honda Karya Utama, as an authorized Honda motorcycle dealer, faces challenges due to unstable monthly sales fluctuations.…
ctuations. This uncertainty complicates stock planning, marketing strategy formulation, and may lead to potential losses caused by overstocking or understocking. To address these issues, this study aims to analyze the relationship between time and sales volume and to develop a predictive model that can assist management in making more effective business decisions.
The research was conducted using a quantitative method and a machine learning approach by applying a linear regression algorithm, implemented through the Python programming language and a MySQL database. The dataset used consists of monthly sales data over one year, analyzed to predict future sales trends. The results show that the linear regression algorithm can predict sales trends with a good level of accuracy, achieving evaluation values of MAPE 1.72%, MSE 1.76%, and RMSE 0.57. The developed model assists management in formulating marketing strategies, optimizing inventory planning, and minimizing financial risks. Therefore, linear regression can serve as an effective analytical tool to support strategic business decision-making at CV. Honda Karya Utama.
Keywords: motorcycle sales; linear regression; prediction; sales analysis
Abstrak: Penjualan sepeda motor merupakan salah satu indikator penting dalam pertumbuhan industri otomotif di Indonesia. CV. Honda Karya Utama sebagai dealer resmi sepeda motor Honda menghadapi tantangan berupa fluktuasi penjualan yang tidak stabil setiap bulannya. Ketidakpastian ini menyebabkan kesulitan dalam perencanaan stok, penentuan strategi pemasaran, serta berpotensi menimbulkan kerugian akibat kelebihan atau kekurangan persediaan. Untuk mengatasi permasalahan tersebut, penelitian ini bertujuan untuk menganalisis hubungan antara waktu dan jumlah penjualan serta membangun model prediksi yang dapat membantu manajemen dalam pengambilan keputusan bisnis yang lebih efektif. Penelitian dilakukan dengan metode kuantitatif dan pendekatan machine learning menggunakan algoritma regresi linier, dengan implementasi berbasis bahasa pemrograman Python dan basis data MySQL. Data yang digunakan berupa data penjualan bulanan selama satu tahun, yang kemudian dianalisis untuk memprediksi tren penjualan pada periode berikutnya. Hasil penelitian menunjukkan bahwa regresi linier mampu memprediksi tren penjualan dengan tingkat akurasi yang baik, dengan nilai evaluasi MAPE sebesar 1,72%, MSE 1,76%, dan RMSE 0,57. Model ini membantu manajemen dalam menyusun strategi pemasaran, mengoptimalkan perencanaan stok, serta meminimalkan risiko kerugian. Dengan demikian, regresi linier dapat menjadi alat bantu yang efektif dalam mendukung keputusan bisnis di CV. Honda Karya Utama.
Kata kunci: penjualan sepeda motor; regresi linier; prediksi; analisis penjualan
Abstract:Abstract: This study aims to analyze the influence of gender on user responses to social media strategies on the Instagram platform by utilizing data science techniques. The methodology includes collecting user interaction…
on data based on gender, statistical analysis, and applying machine learning algorithms to identify response patterns. The results reveal significant differences in how male and female users respond to social media content and campaigns, affecting marketing strategy effectiveness. Data science analysis showed that the K-Means Clustering method segmented users into three groups based on interaction patterns, with female users showing the highest engagement rate (18%) compared to male users (12%). The Decision Tree model identified gender as the most dominant predictor of engagement (40%), followed by user growth (25%) and content type (20%). The Random Forest model validated that gender-targeted strategies increased marketing effectiveness by up to 22%. Multivariate regression revealed a positive effect of female user proportion (+0.45) and a negative effect of male user proportion (−0.12) on engagement. In conclusion, a deeper understanding of gender-based response differences can assist companies in designing more targeted social media strategies and enhancing engagement.
Keywords: gender; social media response; instagram; data science; marketing strategy
Abstrak: Penelitian ini bertujuan untuk menganalisis bagaimana pengaruh gender memengaruhi respons pengguna terhadap strategi media sosial di platform Instagram dengan memanfaatkan teknik data sains. Metode yang digunakan meliputi pengumpulan data interaksi pengguna berdasarkan gender, analisis statistik, dan penerapan algoritma machine learning untuk mengidentifikasi pola respons. Hasil penelitian menunjukkan adanya perbedaan signifikan dalam cara pengguna laki-laki dan perempuan merespons konten dan kampanye media sosial, yang berdampak pada efektivitas strategi pemasaran. Analisis data sains menunjukkan bahwa metode K-Means Clustering berhasil mengelompokkan pengguna ke dalam tiga segmen berdasarkan pola interaksi, dengan segmen perempuan menunjukkan tingkat engagement tertinggi (18%) dibandingkan laki-laki (12%). Model Decision Tree mengidentifikasi gender sebagai faktor paling dominan terhadap engagement dengan kontribusi sebesar 40%, disusul oleh pertumbuhan pengguna (25%) dan jenis konten (20%). Random Forest memvalidasi bahwa strategi yang disesuaikan berdasarkan gender meningkatkan efektivitas pemasaran hingga 22%. Regresi multivariat menunjukkan bahwa proporsi pengguna perempuan berkontribusi positif sebesar 0,45 poin terhadap engagement, sedangkan pengguna laki-laki berkontribusi negatif sebesar -0,12. Kesimpulannya, pemahaman mendalam tentang perbedaan respons berdasarkan gender dapat membantu perusahaan dalam merancang strategi media sosial yang lebih tepat sasaran dan meningkatkan engagement.
Kata kunci: gender; respons media sosial; instagram; data sains; strategi pemasaran
Abstract:Abstract: Palm oil is a key commodity that requires accurate production planning to support budget and operational efficiency. PT Buana Sawit Indah, a company managing palm oil plantations, faces challenges in forecasting…
g future production, necessitating a computerized forecasting system. This study aims to develop a forecasting system using the Single Exponential Smoothing (SES) and Single Moving Average (SMA) methods to predict palm oil production. The results indicate that both methods are effective; however, SMA with a Moving Average (MA) of 5 provides the best forecasting results, with a MAD of 165,941.64, an MSE of 65,823,372,491.27, and an MAPE of 15.66%, categorized as "good" forecasting. Meanwhile, the SES method with α = 0.9 yields the lowest error compared to other alpha values, with a MAD of 154,586.25, an MSE of 33,192,818,696.83, and an MAPE of 16.91%, also classified as "good" forecasting. Based on these findings, the SMA method with MA 5 is recommended as it produces lower forecasting errors than the SES method. Therefore, this forecasting system can assist the company in planning palm oil production more accurately and efficiently, supporting better decision-making in the future.
Keywords: palm oil; forecasting; production; single exponential smoothing; single moving average
Abstrak: Kelapa sawit merupakan komoditas utama yang memerlukan perencanaan produksi yang akurat untuk mendukung efisiensi anggaran dan operasional. PT Buana Sawit Indah, salah satu perusahaan yang mengelola perkebunan kelapa sawit, sedang menghadapi kesulitan dalam memperkirakan hasil produksi di masa mendatang, sehingga diperlukan sistem peramalan berbasis komputer. Penelitian ini bertujuan mengembangkan sistem peramalan menggunakan metode Single Exponential Smoothing (SES) dan Single Moving Average (SMA) untuk memprediksi produksi kelapa sawit. Hasil penelitian menunjukkan bahwa kedua metode cukup efektif, namun SMA dengan Moving Average (MA) 5 memberikan hasil peramalan terbaik dengan nilai MAD sebesar 165.941,64, MSE sebesar 65.823.372.491,27, dan MAPE sebesar 15,66%, yang dikategorikan sebagai peramalan “bagus.†Sementara itu, metode SES dengan α = 0,9 menunjukkan nilai kesalahan lebih rendah dibanding nilai alpha lain, dengan MAD sebesar 154.586,25, MSE sebesar 33.192.818.696,83, dan MAPE sebesar 16,91%, yang juga termasuk kategori peramalan “bagus.†Berdasarkan hasil tersebut, metode SMA dengan MA 5 lebih direkomendasikan karena menghasilkan tingkat kesalahan yang lebih rendah dibandingkan metode SES. Dengan demikian, sistem peramalan ini dapat membantu perusahaan dalam merencanakan produksi kelapa sawit secara lebih akurat dan efisien untuk mendukung pengambilan keputusan yang lebih baik di masa mendatang.
Kata kunci: kelapa sawit; peramalan; produksi; single exponential smoothing; single moving average