Abstract:Antimicrobial resistance has driven the urgent need to develop new antibacterial candidates with favorable efficacy, pharmacokinetic properties, and safety profiles. Aaptamine derivatives, secondary metabolites isolated…
from marine sponges of the genus Aaptos, have demonstrated potential as drug candidates; however, studies evaluating their drug-likeness, Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and toxicity profiles remain limited. This study aimed to prioritize aaptamine, demethyl(oxy)aaptamine, and isoaaptamine as potential antibacterial candidates through SwissADME and ProTox-II analyses using an in silico approach. The results demonstrated that all three compounds satisfied the Lipinski's Rule of Five criteria for drug-likeness, exhibited high gastrointestinal absorption, and achieved a bioavailability score of 0.55. All compounds were predicted to belong to toxicity class 4, with predicted LD₅₀ values of 1300 mg/kg for aaptamine, 500 mg/kg for demethyl(oxy)aaptamine, and 1350 mg/kg for isoaaptamine, while none showed hepatotoxic or cytotoxic properties. The integrated analysis indicated that isoaaptamine exhibited the most balanced drug-likeness, ADME profile, and safety characteristics, making it the highest-priority antibacterial candidate. This study concludes that the integration of SwissADME and ProTox-II provides an effective preliminary approach for screening marine natural product-derived drug candidates. The novelty of this study lies in the integrated application of drug-likeness, ADME, and toxicity analyses to systematically prioritize three aaptamine derivatives, thereby providing a more comprehensive lead compound selection strategy for antibacterial drug discovery.
Abstract:The rapid advancement of information technology has encouraged companies to adopt digital marketing as a strategic approach to enhancing consumer brand awareness. Amanda Brownies Samarinda has utilized various digital platforms;…
atforms; however, the effectiveness of the implemented strategies requires further examination. This study aims to analyze the digital marketing strategies employed by Amanda Brownies Samarinda, their role in enhancing brand awareness, and the factors that support and hinder their effectiveness. A qualitative descriptive approach was employed in this research. Data were collected through observation, structured interviews, and documentation, and subsequently analyzed using the Miles, Huberman, and Saldaña model. The findings reveal that Amanda Brownies Samarinda implements an integrated digital marketing strategy through seven platforms, namely Instagram, Facebook, TikTok, WhatsApp Business, GoFood, GrabFood, and ShopeeFood. These strategies contribute to enhancing brand awareness through four dimensions: recognition, recall, purchase, and consumption. Consistency in visual identity, promotional intensity, ease of access to information, transaction convenience, product quality, and consumer engagement were identified as the primary factors supporting the success of digital marketing implementation. Nevertheless, the utilization of TikTok has not yet been optimized compared to the other platforms. The novelty of this study lies in its comprehensive analysis of the role of integrating seven digital platforms in enhancing brand awareness through the dimensions of recognition, recall, purchase, and consumption, thereby providing a more holistic understanding of digital marketing effectiveness within the culinary industry, particularly at Amanda Brownies Samarinda.
Abstract:Menstruation is a physiological process that can cause regular iron loss in adolescent girls, thereby potentially reducing hemoglobin levels and increasing the risk of anemia if not balanced with adequate iron intake. The…
e research problem focuses on whether the consumption of iron supplementation tablets affects hemoglobin levels during menstruation among adolescent girls at SMK Maesan. This study aims to analyze the effect of iron supplementation on changes in hemoglobin levels using a quasi-experimental design with a control group pretest-posttest approach. The sample consisted of 30 respondents selected through purposive sampling based on inclusion criteria. Hemoglobin levels were measured using the cyanmethemoglobin or Sahli method, accompanied by standard procedures for administering iron supplements. The results of the Wilcoxon statistical test showed a p-value of 0.000 with α<0.05, indicating that the null hypothesis was rejected and the alternative hypothesis was accepted, meaning that there was a significant effect of iron supplementation on increasing hemoglobin levels during menstruation. These findings confirm that the intervention of iron supplementation is effective in improving hemoglobin levels in menstruating adolescent girls. The novelty of this study lies in emphasizing the effectiveness of controlled iron supplementation interventions among vocational high school adolescents using a pretest-posttest approach, thereby providing practical contributions to anemia prevention efforts from an early age through structured and sustainable school health programs.
Abstract:This study aims to empirically analyze the effect of exchange rates and interest rates on the stock prices of banking companies listed on the Indonesia Stock Exchange during the 2020-2024 period. The research employs a quantitative…
uantitative approach with a causal-associative design and utilizes secondary data obtained from official publications of Bank Indonesia (BI) and the Indonesia Stock Exchange (IDX). The research population consists of 45 banking companies, from which 20 companies meeting the sampling criteria were selected using purposive sampling. Data analysis was conducted comprehensively through descriptive analysis, classical assumption tests, multiple linear regression, and hypothesis testing with the assistance of SPSS software. The findings reveal that, partially, exchange rates have a significant negative effect on stock prices, and interest rates also exert a significant negative effect. Furthermore, simultaneous testing confirms that both independent variables significantly and negatively influence banking stock prices. These results highlight that macroeconomic volatility, particularly exchange rate fluctuations and interest rate movements, are crucial determinants to be considered in capital market analysis. Academically, this study contributes to the literature on the relationship between macroeconomic indicators and stock price dynamics, while practically, the results may serve as a reference for investors in making investment decisions, for policymakers in formulating economic stabilization strategies, and for banking institutions in anticipating market risks arising from both global and domestic economic uncertainty.
Abstract:The cognitive development of early childhood requires appropriate stimulation, one of which is through color recognition. Color block media serves as an educational tool that not only introduces various colors but also familiarizes…
amiliarizes children with geometric shapes, numerical concepts, and trains their thinking and memory skills. This study aims to implement color block media as an innovative learning method to effectively improve early childhood abilities in color recognition. Early childhood is a stage of exploration, where the learning process must be concrete, engaging, and enjoyable. Color block media combines visual and manipulative approaches that can foster curiosity and active involvement in the learning process. This learning-through-play activity encourages children to naturally identify, differentiate, and name colors. The study used a quantitative method with a pretest-posttest design to determine the effectiveness of the media. The research was conducted at KB Adduriyah 3 on October 29, 2024, and data analysis was performed using a t-test through SPSS 18 for Windows. The results showed a significance value (2-tailed) of 0.00. Since this value is smaller than the significance level (α = 0.05), the null hypothesis is rejected, and the alternative hypothesis is accepted. The results of the study demonstrate that color block media has a significant impact on improving children's color recognition skills. Additionally, the media also enhances children's active participation in learning activities. Therefore, color block media is highly recommended as a creative and effective learning strategy for educators and parents in supporting the cognitive development of early childhood.
Abstract:Panglipuran Village, Bali, is one of the traditional tourism villages with significant potential to support the economic independence of local communities. However, community empowerment in this village faces various challenges,…
llenges, such as limited resources, a lack of community capacity in management, and dependence on external parties. This study aims to analyze community empowerment based on local participation through the management of the tourism village, using the community empowerment theory proposed by Jim Ife. The study emphasizes the importance of resource, opportunity, knowledge, and skill indicators in supporting the success of community empowerment. This research employs a qualitative descriptive method, collecting data through in-depth interviews, field observations, and documentation. The primary informants of the study include community leaders, local business actors, and tourism village managers. The findings reveal that empowerment through resource indicators has increased the income of craft businesses by 150%, from IDR 2 million to IDR 5 million per month. Furthermore, the opportunity indicator successfully opened avenues for the community to manage homestays, increasing income by up to 70% compared to previous levels. The knowledge and skill indicators also proved significant, with more than 90% of the community actively participating in training, which supports the sustainable economy of the tourism village. The conclusion of this study highlights that community empowerment based on local participation has a positive impact on the economic independence of the Panglipuran Village community. The novelty of this research lies in the integration of community empowerment elements with local wisdom values, such as mutual cooperation and cultural preservation. This model contributes not only to economic development but also serves as a best practice example in sustainable local participation-based tourism village management.
Abstract:Anxiety disorders in teenagers are a serious issue that can impact various aspects of their lives, such as social interactions, academic achievement, and emotional well-being. To address these challenges, group counseling…
g has proven to be an effective approach. In group counseling, teenagers can share their experiences with others facing similar issues, creating a supportive and understanding environment. Techniques like open discussions help them identify the causes of their anxiety more effectively, while role-playing allows them to practice new ways of dealing with anxiety-inducing situations. Relaxation exercises also assist them in developing skills to manage anxiety effectively in their daily lives. Literature studies indicate that group counseling not only reduces anxiety levels in teenagers but also enhances their social skills, self-confidence, and emotional resilience. With support from family, schools, and the community, group counseling can become a sustainable strategy in promoting teenagers' mental well-being. Therefore, it is important to consider that there is no one-size-fits-all approach for all teenagers. However, group counseling provides a safe and structured platform for teenagers to learn from each other, strengthen their coping skills, and make progress in overcoming their anxiety. With this approach, it is hoped that teenagers can build a strong foundation for their ongoing mental health.
Abstract:Tuberculosis (TB) is one of the major health problems in Indonesia, with high rates of spread and social stigma that worsens the condition of survivors. The LAPOR TB platform is present as a digital innovation to support…
TB elimination through increased access to justice and the fulfillment of health rights. This study analyzes the implementation of the LAPOR TB platform from a juridical perspective, using normative research methods that involve legislative and conceptual approaches. The results of the study show that this platform has great potential to improve access to health services for TB survivors, but still faces various legal challenges, including personal data protection, limited access to technology, ineffective complaint mechanisms, and weak law enforcement. Therefore, it is necessary to strengthen legal policies, improve technological infrastructure, and eliminate social stigma to ensure that this platform can run effectively. With these steps, LAPOR TB is expected to be able to support TB elimination efforts and fulfill the right to health for all Indonesian people.
Abstract:Physical fitness is a very important part of everyday life and almost everything that’s done depends on the physical member. In order to function properly, it is essential for us to maintain physical health so as not to…
o cause problems and risk illness. In addition to the illness caused by physical activity, it can also be caused by age actors. In the field of health continues to undergo rapid development, one of the breakthroughs that has been used is the use of ultrasonic waves. Ultrasonic waves are the result of mechanical vibrations produced by the movement of isolated molecules in their diffusion media. If tissues receive ultrasound waves, the impact includes biological effects, mechanical effects and thermal effects. Some of the findings that have been established are the application of ultrasound waves to therapies in cases that appear on physical limbs. On this article aims to be able to contribute in the field of health so that it is easier to develop the use of ultrasonic therapy. This article is compiled using a literature review method taken from the references that have been collected. Of all the references collected, ultrasonic waves are used as therapies for some physical function problems. This therapy also collaborates with several paractic methods of health to address the existing problems. Therapy using ultrasonic modality has been shown to reduce pain, muscle cramps and minor injuries. It can be concluded that ultrasound therapy can help deal with patients suffering from disorders in their physical bodies, either to reduce pain or during the recovery process.
Abstract:Abstract Nowadays, smartphones are not only used for work, but rather as entertainment for children and teenagers, for example online games. The existence of online games has a big impact on teenagers. If you cannot control…
ntrol yourself, you can lose track of time and forget other activities. If online games are overused, it will have detrimental effects. on teenagers’ emotional development. This research aims to analyze the consequence of Mobile Legends addiction to online games on the emotional level of high school students. A literature study was the research methodology employed in this study. Documentation of pertinent journals was the method of data collection employed. Based on the research findings, there appears to be an addictive influence due to playing Mobile Legends the emotional impact of online games of high school students. High school students who are still teenagers have unstable emotions. Addiction to video games can be harmful to students’ emotional levels, namely students become irritable, speak harshly, get easily stressed, anxious and aggressive. Parental war is very important to shield kids from developing a gaming addiction.