Abstract:Antimicrobial resistance has driven the urgent need to develop new antibacterial candidates with favorable efficacy, pharmacokinetic properties, and safety profiles. Aaptamine derivatives, secondary metabolites isolated…
from marine sponges of the genus Aaptos, have demonstrated potential as drug candidates; however, studies evaluating their drug-likeness, Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and toxicity profiles remain limited. This study aimed to prioritize aaptamine, demethyl(oxy)aaptamine, and isoaaptamine as potential antibacterial candidates through SwissADME and ProTox-II analyses using an in silico approach. The results demonstrated that all three compounds satisfied the Lipinski's Rule of Five criteria for drug-likeness, exhibited high gastrointestinal absorption, and achieved a bioavailability score of 0.55. All compounds were predicted to belong to toxicity class 4, with predicted LD₅₀ values of 1300 mg/kg for aaptamine, 500 mg/kg for demethyl(oxy)aaptamine, and 1350 mg/kg for isoaaptamine, while none showed hepatotoxic or cytotoxic properties. The integrated analysis indicated that isoaaptamine exhibited the most balanced drug-likeness, ADME profile, and safety characteristics, making it the highest-priority antibacterial candidate. This study concludes that the integration of SwissADME and ProTox-II provides an effective preliminary approach for screening marine natural product-derived drug candidates. The novelty of this study lies in the integrated application of drug-likeness, ADME, and toxicity analyses to systematically prioritize three aaptamine derivatives, thereby providing a more comprehensive lead compound selection strategy for antibacterial drug discovery.
Abstract:The advancement of digital technology has encouraged the adoption of e-counseling as an integral component of guidance and counseling services in schools. While the use of digital-based services enhances accessibility and…
d flexibility, it also presents various ethical challenges and professional demands for school counselors. This study aims to identify the ethical challenges associated with school-based e-counseling, analyze the professional considerations required of counselors, and examine the interrelationship among ethics, professionalism, and institutional support in the implementation of e-counseling services. The study employed a Systematic Literature Review (SLR) method guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework through a comprehensive search of articles indexed in Google Scholar, GARUDA, ERIC, Scopus, and ProQuest published between 2015 and 2025. The findings reveal that the primary challenges of e-counseling include data confidentiality, client privacy, digital information security, professional boundaries, and limitations in nonverbal communication. The results further indicate that digital competence, adherence to professional ethical standards, and institutional support from schools are critical factors influencing the effectiveness of e-counseling services. This study contributes a conceptual synthesis that positions ethics, counselors’ digital professionalism, and institutional governance as three interrelated pillars essential for the development of safe, ethical, and professional e-counseling practices within school settings.
Abstract:Students can recognize gaining knowledge of material if in the mastering manner they use gear and substances referred to as getting to know media. This tool can take the shape of a physical item, inclusive of sporting out…
out experiments to understand standards in actual terms,
along with melting experiments to search for string wavves. Waves are also known as
vibration phenomena that propagate via a medium or maybe without a medium, these
vibrations may be idea of as oscillations that pass from one factor to another, because the
characteristic of an test is real and additionally uses teaching equipment, as well as an
approach for educators to make college students lively and satisfied in studying. This
observe ambitions to analyze the Melde experiment that's usedto decide the traits of waves
in strings. The test become accomplished by using striking a string and growing waves with
a certain frequency. The analysis effects display that Melde's experiment is powerful in
figuring out the properties of waves in strings, the results of those findings may be utilized
in various fields together with physics and engineering. This research utilized literature as
a method, examine methodology. The ranges in the use of the literature technique are looking
at, analyzing, then figuring out, then ultimately several opinions of the research that has
been achieved. There are 25 published articles acquired from various domestic assets
analyzed in this article. via wearing out a Melde test to determine a wave on a string,
students can discover the primary concepts of mechanical waves and college students begin
to have direct enjoy the use of the Melde experiment. And by means of sporting out the Melde
experiment students can be encouraged to recognize the role of tension, string density, and
string duration within the formation of status waves via statistics evaluation from their
personal experiments and are capable of increase students' talents in facts collection,
information evaluation, and the software of bodily principles to waves on strings in context,
experimental.
Abstract:Abstract Nowadays, smartphones are not only used for work, but rather as entertainment for children and teenagers, for example online games. The existence of online games has a big impact on teenagers. If you cannot control…
ntrol yourself, you can lose track of time and forget other activities. If online games are overused, it will have detrimental effects. on teenagers’ emotional development. This research aims to analyze the consequence of Mobile Legends addiction to online games on the emotional level of high school students. A literature study was the research methodology employed in this study. Documentation of pertinent journals was the method of data collection employed. Based on the research findings, there appears to be an addictive influence due to playing Mobile Legends the emotional impact of online games of high school students. High school students who are still teenagers have unstable emotions. Addiction to video games can be harmful to students’ emotional levels, namely students become irritable, speak harshly, get easily stressed, anxious and aggressive. Parental war is very important to shield kids from developing a gaming addiction.
Abstract:Over time, engaging in tourism has evolved into a necessity for acquiring delightful experiences. However, such tourism activities also carry inherent risks that can potentially harm visitors. This research, adopting a qualitative…
ualitative approach through a literature study, employs data collection methods by referencing legal documents, pertinent articles, and books relevant to the study. The research findings underscore that legal frameworks guarantee the rights of tourists to protection, safety, and security. Consequently, it is imperative for tourism managers to prioritize the safety of visitors arising from the activities involved. This involves the implementation of robust Standard Operating Procedures (SOP), effective mitigation procedures, optimal functioning of infrastructure, provision of adequate safety equipment, and continuous enhancement of staff competencies. Owners of tourist attractions bear the responsibility of ensuring both the safety and legal protection of visitors, acknowledging the mutual benefits derived from the presence of tourists. Thus, a comprehensive and proactive approach to safety measures is essential in fostering a secure and enjoyable environment for all visitors.
Abstract:To maximize customer satisfaction through marketing strategies residential property companies must understand the dynamics of appropriate marketing strategies. One of them is by maximizing consumer satisfaction with several…
ral important factors such as product, price, promotion and place. The aim of this research is to analyze the influence of the marketing mix on consumer satisfaction at Astapada Indah III Jombang housing. This type of research uses quantitative research with a cross-sectional study approach. The population of all residents of the Astapada Indah III housing complex was 68 and the sample was 58 people using incidental sampling technique. The independent variables are product, price, promotion, place and the dependent variable is consumer satisfaction. The research instruments used questionnaires, data processing using multiple linear regression tests. The results of the research showed that product and location had a significant effect on housing consumer satisfaction, while price and promotion had no effect on consumer satisfaction. However, simultaneously product, price, promotion and location all influence consumer behavior simultaneously by 79.4%.
Abstract:The aims of this study is to determine the ability of class VIII students at MTs Jamilurrahman As-Salafy Yogyakarta in Arabic. Arabic is one of the main subjects in this madrasah, and the mastery of four Arabic language…
skills. The four skills are listening (istima'), speaking (kalam), reading (qiroah), and writing (kitabah) are very important in the learning process. The research method used was my research with a descriptive approach. Data were obtained through written and oral Arabic tests conducted on students of class VIII. The test results were categorised into several score ranges, and the students' Arabic language skills were analysed based on the predicates obtained. The results showed that most of the students had deficient Arabic language skills, with 48% of the total students being at the predicate of "Deficient". A total of 21% of students got the predicate "Very Good," 19% of students got the predicate "Good," and 12% of students got the predicate "Fair." The study also noted factors that influence students' Arabic language proficiency, including learning methods, textbooks, materials, educational institutions and time. Madrasah Tsanawiyah Jamilurrahman As-Salafy Putri Yogyakarta plays an important role in shaping students' Arabic language skills, but there are challenges in improving overall Arabic language skills. This study provides an understanding of the status of students' Arabic language skills at MTs Jamilurrahman As-Salafy Putri Yogyakarta and shows the importance of developing Arabic language learning at the madrasah.
Abstract:Hak Asasi Manusia (HAM) merupakan hak dasar yang melekat pada setiap manusia sejak lahir. Dalam perspektif Islam, khususnya Al-Qur’an, konsep HAM tidak hanya dipandang sebagai hak individual, tetapi juga sebagai bagian dari…
dari tanggung jawab moral dan spiritual manusia terhadap sesama. Al-Qur’an menempatkan manusia sebagai makhluk yang dimuliakan oleh Allah SWT dan memiliki kedudukan yang sama di hadapan-Nya tanpa membedakan ras, suku, maupun status sosial. Penelitian ini bertujuan untuk menjelaskan pandangan Al-Qur’an mengenai HAM dalam konsep kemanusiaan melalui pendekatan studi kepustakaan. Hasil kajian menunjukkan bahwa Al-Qur’an mengandung prinsip-prinsip HAM seperti hak hidup, kebebasan beragama, keadilan, persamaan, dan penghormatan terhadap martabat manusia. Nilai-nilai tersebut menjadi dasar terciptanya kehidupan masyarakat yang damai, adil, dan berperikemanusiaan.
Abstract: pemanfaatan teknologi kecerdasan buatan era 4.0 (Artificial Intelligence/AI) menjadi salah satu faktor yang menghambat peningkatan kualitas publikasi di Lembaga Paspama Institute. Selama ini, proses penyusunan…
penyusunan naskah, pengolahan data, dan penyuntingan artikel masih dilakukan secara konvensional, sehingga memerlukan waktu lama dan sering kali menghasilkan kualitas tulisan yang tidak konsisten. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan literasi digital dan kemampuan praktis peserta dalam memanfaatkan teknologi AI guna memperbaiki efektivitas serta mutu publikasi ilmiah di lingkungan Paspama Institute. Metode pelaksanaan kegiatan dilakukan melalui pendekatan pelatihan dan pendampingan interaktif, meliputi tiga tahapan utama: (1) pengenalan konsep dasar AI dan potensinya dalam bidang publikasi, (2) workshop penerapan aplikasi AI seperti ChatGPT, Grammarly, dan Copilot untuk asistensi penulisan akademik, serta (3) pendampingan penyusunan artikel ilmiah berbasis AI secara etis dan bertanggung jawab. Hasil kegiatan menunjukkan peningkatan signifikan pada kemampuan peserta dalam menulis dan mengedit naskah, dengan nilai rata-rata post-test meningkat sebesar 32% dibandingkan pre-test. Selain itu, peserta menunjukkan peningkatan kepercayaan diri dalam menggunakan teknologi digital untuk kegiatan publikasi. Kegiatan ini berdampak positif terhadap penguatan kapasitas sumber daya manusia Paspama Institute dalam menghasilkan karya ilmiah yang lebih berkualitas, efisien, dan adaptif terhadap perkembangan teknologi digital
Abstract:Penelitian ini membahas tentang nilai-nilai teologi Islam melalui pelatihan dan pendampingan fardhu kifayah terhadap pengurusan jenazah di di Desa Simpang Dolok Kecamatan Lima Puluh Kabupaten Batu Bara. Fardhu kifayah disini…
sini maksudnya adalah dalam hal mengurus jenazah yang mengandung nilai-nilai teologi Islam seperti keimanan, tanggung jawab, kepedulian sosial, serta hak dan kewajiban sebagai hamba Allah SWT. Ada empat kewajiban umat Islam setelah meninggalnya seseorang, yaitu memandikan, mengkafankan, mengsholatkan dan menguburkan. Pelatiahan dan pendampingan terkait pelaksanaan fardhu kifayah ini dilakukan dilokasi simpang dolok tepatnya di Mushollah Sekolah Tinggi Ilmu Tarbiyah Batu Bara, kegiataan ini di laksanakan agar meningkatkan keterampilan masyarakat, yang terdiri dari mahasiswa dan mahasiswi dan para ramaja mesjid di sekitaran desa simpang dolok tujuannya adalah agar mareka mengerti dan paham dalam hal pengurusan jenazah sebagaimana tuntunan yang sesuai syari’at Islam sehingga apa bila suatu saat di butuhkan mareka siap.