Abstract:Antimicrobial resistance has driven the urgent need to develop new antibacterial candidates with favorable efficacy, pharmacokinetic properties, and safety profiles. Aaptamine derivatives, secondary metabolites isolated…
from marine sponges of the genus Aaptos, have demonstrated potential as drug candidates; however, studies evaluating their drug-likeness, Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and toxicity profiles remain limited. This study aimed to prioritize aaptamine, demethyl(oxy)aaptamine, and isoaaptamine as potential antibacterial candidates through SwissADME and ProTox-II analyses using an in silico approach. The results demonstrated that all three compounds satisfied the Lipinski's Rule of Five criteria for drug-likeness, exhibited high gastrointestinal absorption, and achieved a bioavailability score of 0.55. All compounds were predicted to belong to toxicity class 4, with predicted LD₅₀ values of 1300 mg/kg for aaptamine, 500 mg/kg for demethyl(oxy)aaptamine, and 1350 mg/kg for isoaaptamine, while none showed hepatotoxic or cytotoxic properties. The integrated analysis indicated that isoaaptamine exhibited the most balanced drug-likeness, ADME profile, and safety characteristics, making it the highest-priority antibacterial candidate. This study concludes that the integration of SwissADME and ProTox-II provides an effective preliminary approach for screening marine natural product-derived drug candidates. The novelty of this study lies in the integrated application of drug-likeness, ADME, and toxicity analyses to systematically prioritize three aaptamine derivatives, thereby providing a more comprehensive lead compound selection strategy for antibacterial drug discovery.
Abstract:The development of Generative Artificial Intelligence (GenAI) has created new opportunities to develop more adaptive learning while enhancing students' digital literacy. This study aims to analyze the implementation of GenAI…
enAI as an adaptive learning medium, its effect on improving digital literacy, and Information Systems students' perceptions of its use. This research employed a quantitative approach using a pre-experimental method with a one-group pre-test and post-test design. The results showed that the average digital literacy score increased from 68.8 to 85.0, representing an improvement of 16.2 points after the implementation of GenAI. The highest improvement was found in the Digital Safety and Ethics dimension with 19 points, followed by Digital Content Creation with 17 points, Information Literacy and Digital Technology Utilization with 16 points each, and Digital Communication and Collaboration with 13 points. The paired sample t-test produced a t-value of 8.45 with a significance level of 0.000, indicating that the implementation of GenAI had a statistically significant effect on improving students' digital literacy. The students also expressed positive perceptions of GenAI because it facilitated their understanding of learning materials, increased learning motivation, and supported more effective completion of academic tasks. This study concludes that GenAI is an effective adaptive learning medium for improving students' digital literacy. The novelty of this study lies in the development of a GenAI implementation model that integrates adaptive learning with the five dimensions of digital literacy among Information Systems students in a comprehensive manner.
Abstract:Market manipulation practices in the Indonesian capital market have the potential to harm investors, distort fair price formation, and undermine market integrity. These conditions require effective supervision by the Financial…
ancial Services Authority (Otoritas Jasa Keuangan—OJK) as the institution authorized to regulate and supervise capital market activities. This study aims to analyze the legal framework governing OJK's supervision of market manipulation practices, assess the effectiveness of its implementation, and identify the factors influencing the success of such supervision. This study employed a normative legal research method using statutory and conceptual approaches. Legal materials were collected through library research and analyzed qualitatively. The findings indicate that OJK's supervisory authority is supported by a strong legal framework under Law Number 8 of 1995 concerning the Capital Market and Law Number 21 of 2011 concerning the Financial Services Authority. Nevertheless, the effectiveness of supervision continues to face challenges arising from technological developments, the increasing complexity of market manipulation schemes, and limitations in supervisory capacity. This study concludes that strengthening institutional capacity, optimizing the use of technology, and enhancing inter-agency coordination are essential to improving investor protection and maintaining the integrity of the capital market. The novelty of this study lies in its integrated analysis of the legal framework, supervisory effectiveness, and technology-based market manipulation challenges within a single analytical framework.
Abstract:The advancement of financial technology has encouraged Islamic boarding schools to implement digital transaction systems to improve the effectiveness of cooperative services. This study aims to analyze the ease of use of…
the student digital card and identify the supporting and inhibiting factors affecting its implementation at Hidsam Mart Cooperative, Hidayatullah Islamic Boarding School, Samarinda. The study employed a descriptive qualitative approach using observation, semi-structured interviews, and documentation, with data analyzed through the interactive model of Miles, Huberman, and Saldaña. The findings indicate that the student digital card is easy to understand, operate, access, and learn, thereby accelerating transaction processes, improving service efficiency, and supporting more systematic financial record-keeping. The main obstacles identified include technical disruptions, network limitations, and the absence of independent features for checking account balances and transaction histories. The novelty of this study lies in its specific analysis of the ease of use of student digital cards within the context of an Islamic boarding school cooperative by emphasizing user experience as the primary basis for evaluating the implementation of a digital transaction system. The findings are expected to serve as a reference for the development of digital transaction services in Islamic boarding school environments.
Abstract:Employee performance is a crucial factor in supporting the success of government organizations in achieving public service objectives. The Department of Education and Culture of Jayapura City continues to face various challenges…
allenges related to work motivation, work discipline, and the work environment, which are presumed to influence employee performance. This study aims to analyze the effects of work motivation, work discipline, and the work environment on employee performance, both partially and simultaneously. The research employed a quantitative approach with an explanatory research design. The study population consisted of 87 employees, all of whom were selected as respondents through a saturated sampling technique. Data were collected using questionnaires and analyzed through multiple linear regression with the assistance of IBM SPSS Statistics. The findings reveal that work motivation has a positive and significant effect on employee performance, with a significance value of 0.002 and a regression coefficient of 0.388. Work discipline also demonstrates a positive and significant effect, with a significance value of 0.002 and a regression coefficient of 0.310. The work environment emerges as the most dominant variable, with a significance value of 0.000, a regression coefficient of 1.238, and a beta coefficient of 0.417. Simultaneously, work motivation, work discipline, and the work environment significantly influence employee performance, as indicated by an F-statistic of 40.438 and a significance value of 0.000. The coefficient of determination (R Square) of 0.594 indicates that 59.4% of the variation in employee performance can be explained by these three variables. The novelty of this study lies in its empirical evidence that the work environment constitutes the most dominant factor affecting employee performance within the Department of Education and Culture of Jayapura City, an institution characterized by distinctive organizational features and service-area conditions.
Abstract:The rapid advancement of information technology has encouraged companies to adopt digital marketing as a strategic approach to enhancing consumer brand awareness. Amanda Brownies Samarinda has utilized various digital platforms;…
atforms; however, the effectiveness of the implemented strategies requires further examination. This study aims to analyze the digital marketing strategies employed by Amanda Brownies Samarinda, their role in enhancing brand awareness, and the factors that support and hinder their effectiveness. A qualitative descriptive approach was employed in this research. Data were collected through observation, structured interviews, and documentation, and subsequently analyzed using the Miles, Huberman, and Saldaña model. The findings reveal that Amanda Brownies Samarinda implements an integrated digital marketing strategy through seven platforms, namely Instagram, Facebook, TikTok, WhatsApp Business, GoFood, GrabFood, and ShopeeFood. These strategies contribute to enhancing brand awareness through four dimensions: recognition, recall, purchase, and consumption. Consistency in visual identity, promotional intensity, ease of access to information, transaction convenience, product quality, and consumer engagement were identified as the primary factors supporting the success of digital marketing implementation. Nevertheless, the utilization of TikTok has not yet been optimized compared to the other platforms. The novelty of this study lies in its comprehensive analysis of the role of integrating seven digital platforms in enhancing brand awareness through the dimensions of recognition, recall, purchase, and consumption, thereby providing a more holistic understanding of digital marketing effectiveness within the culinary industry, particularly at Amanda Brownies Samarinda.
Abstract:Bankruptcy risk is a critical issue for publicly listed companies as it may threaten business sustainability and undermine investor confidence. This study aims to examine the effects of asset growth, revenue growth, market…
et valuation, property, plant and equipment (PPE), goodwill, and research and development expenditure on bankruptcy risk, proxied by the Altman Z-score, among publicly listed companies in ASEAN countries. The study employs a quantitative approach using secondary data obtained from 1,354 non-financial firms listed in Indonesia, Malaysia, Thailand, Singapore, and the Philippines over the 2015–2023 period, yielding a total of 7,726 firm-year observations. Data were analyzed using a fixed-effects panel regression model. The findings reveal that asset growth and goodwill exert a positive and significant effect on the Altman Z-score, whereas research and development expenditure has a negative and significant effect. Revenue growth demonstrates a marginally positive influence, while market valuation and PPE do not exhibit a significant effect on bankruptcy risk. These results suggest that corporate financial stability is determined not only by financial factors but also by the quality of strategic resources and firms’ adaptive capabilities. The novelty of this study lies in the integration of the Resource-Based View and Dynamic Capabilities Theory perspectives into a bankruptcy prediction framework for publicly listed companies across ASEAN countries.
Abstract:Zakat is an Islamic economic instrument that plays a significant role in enhancing social welfare and promoting equitable socioeconomic development. The effectiveness of zakat management is strongly influenced by the accountability…
ountability and transparency practices implemented by zakat management institutions. This study aims to explore the practices of accountability and transparency in zakat fund management at the National Board of Zakat (BAZNAS) of Sumbawa Regency and to examine their contribution to public trust. A descriptive qualitative approach was employed, with data collected through interviews, observations, and document analysis. The findings reveal that accountability has been implemented through financial reporting in accordance with PSAK 109, external auditing, and structured accountability mechanisms. Transparency is demonstrated through the dissemination of information via the official website, social media platforms, print media, and public outreach activities. The implementation of these principles contributes to strengthening the trust of muzakki (zakat payers) and generating tangible benefits for mustahik (zakat beneficiaries), although improvements in information accessibility and the development of productive zakat programs remain necessary. The novelty of this study lies in its exploration of the interrelationship between accountability, transparency, muzakki trust, and the perceived benefits experienced by mustahik within the context of regional zakat management at BAZNAS Sumbawa Regency.
Abstract:Daiama Tourism Village in Rote Ndao Regency possesses significant natural and cultural tourism potential; however, its tourism promotion remains suboptimal, resulting in fluctuating tourist visitation rates. This study aims…
ims to analyze promotional activities, identify factors influencing promotional effectiveness, and formulate promotional strategies to increase tourist visits. The research employed a qualitative descriptive method through observation, interviews, literature review, and documentation, supported by interactive data analysis and triangulation techniques. The findings reveal that promotional efforts still rely primarily on annual festivals and direct interpersonal communication without systematic support from planned digital media. This condition has contributed to fluctuations in tourist arrivals, increasing from 587 visitors in 2022 to 711 visitors in 2023, before declining to 503 visitors in 2024 and 468 visitors in 2025. Constraining factors include limited human resources, weak digital media management, and the underdeveloped institutional capacity of the Tourism Awareness Group (Pokdarwis). The study concludes that promotional strategies should be directed toward digital marketing, strengthening cultural identity and local storytelling, as well as enhancing community and institutional capacity. The novelty of this study lies in the development of a sustainable promotional model that integrates digital marketing, cultural storytelling, community participation, and the strengthening of Pokdarwis institutions in accordance with the characteristics of Daiama Tourism Village as a nature- and culture-based tourism destination.
Abstract:The advancement of digital technology has encouraged the adoption of e-counseling as an integral component of guidance and counseling services in schools. While the use of digital-based services enhances accessibility and…
d flexibility, it also presents various ethical challenges and professional demands for school counselors. This study aims to identify the ethical challenges associated with school-based e-counseling, analyze the professional considerations required of counselors, and examine the interrelationship among ethics, professionalism, and institutional support in the implementation of e-counseling services. The study employed a Systematic Literature Review (SLR) method guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework through a comprehensive search of articles indexed in Google Scholar, GARUDA, ERIC, Scopus, and ProQuest published between 2015 and 2025. The findings reveal that the primary challenges of e-counseling include data confidentiality, client privacy, digital information security, professional boundaries, and limitations in nonverbal communication. The results further indicate that digital competence, adherence to professional ethical standards, and institutional support from schools are critical factors influencing the effectiveness of e-counseling services. This study contributes a conceptual synthesis that positions ethics, counselors’ digital professionalism, and institutional governance as three interrelated pillars essential for the development of safe, ethical, and professional e-counseling practices within school settings.